Strain information
 NBRP Rat No: 0014  Strain name: TM/Kyo  Commmon Name: tester Moriyama rat Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email: serikawa@anim.med.kyoto-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  fawn hooded (a,B,C,h,P,r)
Inbred Generations  F20+102 (March 2012)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Genetically Modified (GM)  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Rab38: Rab38, member of RAS oncogene family. ruby or red eyed dilution
Origin Tester Moriyama rat derived from Long-Evans at Aichi Cancer Center, were transferred to Moriyama Mental Disease Hospital and Nagoya University. Inbred Line was established at Nagoya University. From Shionogi & Co., Ltd. to Kyo in 1976 .
Strain characteristics Used as caot color tester line modified blood caogulation and platelet derived serotonin release was detected. Used as an animal model for platelet storage pool deficiency. TM has a Met1Ile mutation at the translation initiation codon of the Rab38 gene. This mutation is shared with FH rat, showing similar phenotypes to TM rats.
Breeding Conditions Good breeding performance. Sib mating.
Genotyping
References Hamada S, Serikawa T, Yamada J.
TMラットの止血時間延長に関する遺伝学的検索
第32回日本実験動物学会総会講演要旨集. p117, 1985

Hamada S, Nishikawa T, Yokoi N, Serikawa T.
TM rats: a model for platelet storage pool deficiency.
Exp Anim. 1997 Jul;46(3):235-9.

Fujimori H, Ozaki K, Nomura S, Nishikawa T, Pan-Hou H, Nishimura M, Narama I.
Characterization of platelet abnormalities of Tester Moriyama (TM) rats with storage pool deficiency.
Lab Anim Sci. 1998 Oct;48(5):490-5.

Oiso N, Riddle SR, Serikawa T, Kuramoto T, Spritz RA.
The rat Ruby ( R) locus is Rab38: identical mutations in Fawn-hooded and Tester-Moriyama rats derived from an ancestral Long Evans rat sub-strain.
Mamm Genome. 2004 Apr;15(4):307-14.

Kuramoto T, Nakanishi S, Ochiai M, Nakagama H, Voigt B, Serikawa T.
Origins of Albino and Hooded Rats: Implications from Molecular Genetic Analysis across Modern Laboratory Rat Strains.
PLoS One. 2012;7(8):e43059.
Additional strain information TM