NBRP Rat No: 0014
Commmon Name: tester Moriyama rat
Rat Genome Database
Tadao Serikawa Graduate School of Medicine, Kyoto University Yoshidakonoe-cho, Sakyo-ku 606-8501 Kyoto JAPAN
Tel: 075-753-4360 Fax: 075-753-4409
fawn hooded (a,B,C,h,P,r)
F20+102 (March 2012)
Genetically Modified (GM)
Research Area Others
Rab38: Rab38, member of RAS oncogene family. ruby or red eyed dilution
Tester Moriyama rat derived from Long-Evans at Aichi Cancer Center, were transferred to Moriyama Mental Disease Hospital and Nagoya University. Inbred Line was established at Nagoya University. From Shionogi & Co., Ltd. to Kyo in 1976 .
Used as caot color tester line modified blood caogulation and platelet derived serotonin release was detected. Used as an animal model for platelet storage pool deficiency. TM has a Met1Ile mutation at the translation initiation codon of the Rab38 gene. This mutation is shared with FH rat, showing similar phenotypes to TM rats.
Good breeding performance. Sib mating.
Hamada S, Serikawa T, Yamada J.
第32回日本実験動物学会総会講演要旨集． p117, 1985
Hamada S, Nishikawa T, Yokoi N, Serikawa T.
TM rats: a model for platelet storage pool deficiency.
Exp Anim. 1997 Jul;46(3):235-9.
Fujimori H, Ozaki K, Nomura S, Nishikawa T, Pan-Hou H, Nishimura M, Narama I.
Characterization of platelet abnormalities of Tester Moriyama (TM) rats with storage pool deficiency.
Lab Anim Sci. 1998 Oct;48(5):490-5.
Oiso N, Riddle SR, Serikawa T, Kuramoto T, Spritz RA.
The rat Ruby ( R) locus is Rab38: identical mutations in Fawn-hooded and Tester-Moriyama rats derived from an ancestral Long Evans rat sub-strain.
Mamm Genome. 2004 Apr;15(4):307-14.
Kuramoto T, Nakanishi S, Ochiai M, Nakagama H, Voigt B, Serikawa T.
Origins of Albino and Hooded Rats: Implications from Molecular Genetic Analysis across Modern Laboratory Rat Strains.
PLoS One. 2012;7(8):e43059.
Additional strain information