Strain information
 NBRP Rat No: 0645  Strain name: HAP/Hshyo  Commmon Name: high alcohol preference rat Rat Genome Database
Principal Investigator:  Minori Nishiguchi   Hyogo College of Medicine       1-1 Mukogawa-cho, Nishinomiya    663-8501 Hyogo     Japan
Tel: +81-798-45-6578    Fax: +81-798-49-3279 Email: m-nishig@hyo-med.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  白
Inbred Generations  60代目
Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
1) Liver sytosolic aldehyde dehydrogenase (ALDH1) polymorphism and its inheritance in Wistar rats. Negoro, M., Hatake, K, Taniguchi, T., Ouchi, H., Minami, T. and Hishida, S. Jpn. J. Alcohol & Drug Dependence, 32(3): 182-188, 1997.
2) Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model system. Nishiguchi, M., Kinoshita, H.., Mostofa, J., Taniguchi, T., Ouchi, H., Minami, T., Hatake, K, Utsumi, T., Motomura, H. and Hishida, S. Alcohol. Alcohol., 37(1):9-12, 2002.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others アルコール医学
 Control Strain  Marker Strain
Gene Affected
Origin High alcohol-preference (HAP) rats and Low alcohol-preference (LAP) rats were developed in the laboratory, Department of Legal Medicine, Hyogo College of Medicine, by selective inbreeding from the Wistar colony of rats. The ethanol preference of the rats was assessed by the one-lever two-liquid chamber method. (Iso and Sakaki, 1982).
Strain characteristics HAP and LAP rats show different ALDH1 phenotypes, different blood acetaldehyde concentration following ethanol administration, and different expression level of corticosterone and proopioomeranocortin. Furthermore HAP have a significantly higher sensitivity than LAP for methamphetamine.
Breeding Conditions
Genotyping
References 1)　 Liver sytosolic aldehyde dehydrogenase (ALDH1) polymorphism and its inheritance in Wistar rats. Negoro, M., Hatake, K., Taniguchi, T., Ouchi, H., Minami, T. and Hishida, S. Jpn. J. Alcohol & Drug Dependence, 32 (3): 182-188, 1997.
2) アルコールの併用は高アルコール嗜好性ラットにおける覚せい剤の中枢神経作用を増強する. 山内順子, 丸川征四郎, 菱田　繁. 日本アルコール・薬物医学会雑誌, 35(1):28-47. 2000.
3) Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model system. Nishiguchi, M., Kinoshita, H., Mostofa, J., Taniguchi, T., Ouchi, H., Minami, T., Hatake, K., Utsumi, T., Motomura, H. and Hishida, S. Alcohol. Alcohol., 37 (1): 9-12, 2002.
4) 慢性アルコール摂取が覚せい剤の脳内ドパミンおよびセロトニン変化に及ぼす影響－アルコール嗜好性の異なるラット間での比較検討－. 西口美紀, 木下博之, 谷口忠昭, 内海隆生, 大内晴美, 南　貴子, 菱田　繁. Jpn. J. Alcohol & Drug Dependence, 37(6):555-576, 2002.
5) Decreased histamine-stimulated phosphoinositide hydrolysis in the cerebral cortex of arat line selectively bred for high alcohol preference. Kitanaka. N., Kitanaka. J., Nishiguchi. M., Kinoshota, H., et al. Neurochem Res. 29(7):1431-1436. 2004.
6) High alcohol preferring (HAP) and low alcohol preferring (LAP) rats show altered proopioomeranocortin (POMC) messenger RNA expression in the arcuate nucleus. Kinoshita, H., Harbuz, S. M., Nishiguchi, M., et al. Alcohol & Alcoholism, 39(5):406-409，2004.
7) Corticosterone concentration following ethanol administration in high alcohol preferring (HAP) and low alcohol preferring (LAP) rats. Kinoshita H, Takahashi M, Matsui K, Nishiguchi M, Ouchi H, Minami T, Hishida S, Jamal M, Ameno K. Current Study of Environmental and Medical Sciences 2:13-5, 2009.
8) Effects of dopamine antagonists on methamphetamine-induced dopamine release in high and low alcohol preference rats. Nishiguchi M, Kinoshita H, Kasuda S, Takahashi M, Yamamura T, Matsui K, Ouchi H, Minami T, Hishida S, Nishio H. Toxicology Mechanisms and Methods 20(3):127-132, 2010.
Additional strain information