Strain information
 NBRP Rat No: 0630  Strain name: PVG.KDP-Cblb/Nyo  Commmon Name: PVG.KDP-Cblb congenic, PK congenic Rat Genome Database
Principal Investigator:  Norihide Yokoi  Kobe University Graduate School of Medicine       Kobe BT Center, 1-5-6, Minatojima Minami-cho, Chuo-ku, Kobe    650-0047 Hyogo     Ｊａｐａｎ
Tel: 078-304-6046    Fax: 078-304-6057 Email: yokoi@med.kobe-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  black hooded(a,B,C,h)
Inbred Generations  N8F10 (2010.11.1)
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The recipients shall cite the references of the resource and acknowledge the depositor as the source of the resource in the publications. Depending on the project of the recipients, a collaborative arrangement with the depositor could be required. In this case, the recipients shall discuss with the depositor.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Cblb, Casitas B-Lineage lymphoma b
Origin The Cblb region, one of the causative gene in type 1 diabetes of KDP/Tky was transferred onto the genetic background of PVG.R23 strain.
Strain characteristics Although type 1 diabates and insulitis are not observed in this strains, thyroiditis is often observed.
Breeding Conditions
Genotyping
References Komeda K, Noda M, Terao K, Kuzuya N, Kanazawa M, Kanazawa Y. Establishment of two substrains, diabetes-prone and non-diabetic, from Long-Evans Tokushima Lean (LETL) rats. Endocr J. 45(6):737-44, 1998. Yokoi N, Komeda K, Wang HY, Yano H, Kitada K, Saitoh Y, Seino Y, Yasuda K, Serikawa T, Seino S. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet. 31(4):391-4, 2002 Yokoi N, Namae M, Fuse M, Wang HY, Hirata T, Seino S, Komeda K. Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain. Exp Anim. 52(4):295-301, 2003
Additional strain information