Strain information
 NBRP Rat No: 0649  Strain name: F344-Atmem1Kyo  Commmon Name: ZFN-Atm Rat Genome Database
Principal Investigator:  Tomoji Mashimo  The University of Tokyo, The Institute of Medical Science       4-6-1 Shirokanedai-Minatoku-Tokyoto    108-8639      Japan
Tel: 03-6409-2489    Fax:  Email: mashimo@ims.u-tokyo.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals ?s_Neurobiology=1 ?s_Neurobiology=1
Coat Color  albino (c)
Inbred Generations  N1 (April 2012)
Usage Restrictions  利用者は事前に寄託者の提供承諾書を得ること。
商用に使用する際には、本同意書とは別に、寄託者と契約を結ばねばならない。
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Atm: ataxia telangiectasia mutated
Origin This rat strain was established by ZFN method targeting rat Atm gene (resulting in a 8-bp deletion of exon13). Background strain: F344/Stm
Strain characteristics Ataxia-telangiectasia (A-T) model. Atm knockout rat does not display cerebellar atrophy but instead paralysis and spinal cord atrophy. Loss of Atm in neurons and glia leads to accumulation of cytosolic DNA, increased cytokine production and constitutive activation of microglia consistent with a neuroinflammatory phenotype. Rats lacking ATM had significant loss of motor neurons and microgliosis in the spinal cord, consistent with onset of paralysis.　 Atm KO rats also developed lymphomas and occasional solid tumours similar to the cancer types seen in A-T patients. Other detailed phenotypes are described in the reference article. (March 2017)
Breeding Conditions Mmintained by crossing between Atm heterozygous rats. (Homozygous rats are infertility.)
Genotyping Genotyping protocol for Atm
References Quek h, Luff J, Cheung K, Kozlov S, Gatei M, Lee CS, Bellingham MC, Noakes PG, Lim YC, Barnett NL, Dingwall S, Wolvetang E, Mashimo T, Roberts TL, Lavin MF.
A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype.
Hum Mol Genet. 2016 Dec 22. pii: ddw371.
Additional strain information