NBRP Rat No: 0656 |
Strain name: F344-Lgi1m1Kyo |
Commmon Name: Lgi1 mutant rat |
Rat Genome Database |
Principal Investigator: |
Tomoji Mashimo The University of Tokyo, The Institute of Medical Science 4-6-1 Shirokanedai-Minatoku-Tokyoto 108-8639 Japan |
Tel: 03-6409-2489 Fax: |
Email: mashimo@ims.u-tokyo.ac.jp |
Preservation Status: |
Embryo Sperm Living Animals |
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Coat Color |
albino (c) |
Inbred Generations |
N10 (NOV, 2011) |
Usage Restrictions |
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. |
Genetic Status |
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Comercial Availability |
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Research Category |
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Gene Affected |
Lgi1 |
Origin |
Developped by gene driven ENU mutagenesis. Lgi1-mutant rats carrying a missense mutation (L385R). |
Strain characteristics |
This rats carrying a missense mutation (L385R) in Lgi1 gene and shows high susceptibility to sound-induced, generalized tonic-clonic seizures.
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Breeding Conditions |
Good breeding performance. |
Genotyping |
Genotyping protocol for Lgi1 |
References |
Kinboshi M, Shimizu S, Tokudome K, Mashimo T, Serikawa T, Ito H, Takahashi R, Ikeda A, Ohno Y.
Imbalance of glutamatergic and GABAergic neurotransmission in audiogenic seizure-susceptible Leucine-rich glioma-inactivated 1 (Lgi1)-mutant rats.
Heliyon. 2023 Jul 5;9(7):e17984.
Kinboshi M, Shimizu S, Mashimo T, Serikawa T, Ito H, Ikeda A, Takahashi R, Ohno Y.
Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats.
Int J Mol Sci. 2019 Feb 26;20(5):1013.
Serikawa T, Mashimo T, Kuramoto T, Voigt B, Ohno Y, Sasa M.
Advances on Genetic Rat Models of Epilepsy.
Exp Anim. 64(1):1-7, 2015.
"A rat model for LGI1-related epilepsies.
Baulac S, Ishida S, Mashimo T, Boillot M, Fumoto N, Kuwamura M, Ohno Y, Takizawa A, Aoto T, Ueda M, Ikeda A, LeGuern E, Takahashi R, Serikawa T.
Hum Mol Genet. 2012 Aug 15;21(16):3546-57. |
Additional strain information |
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