Strain information  NBRP Rat No: 0656  Strain name: F344-Lgi1m1Kyo  Commmon Name: Lgi1 mutant rat Rat Genome Database Principal Investigator:  Tomoji Mashimo  The University of Tokyo, The Institute of Medical Science       4-6-1 Shirokanedai-Minatoku-Tokyoto    108-8639      Japan Tel: 03-6409-2489    Fax:  Email: mashimo@ims.u-tokyo.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  N10 (NOV, 2011) Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Lgi1 Origin Developped by gene driven ENU mutagenesis. Lgi1-mutant rats carrying a missense mutation (L385R). Strain characteristics This rats carrying a missense mutation (L385R) in Lgi1 gene and shows high susceptibility to sound-induced, generalized tonic-clonic seizures. Breeding Conditions Good breeding performance. Genotyping Genotyping protocol for Lgi1 References Serikawa T, Mashimo T, Kuramoto T, Voigt B, Ohno Y, Sasa M. Advances on Genetic Rat Models of Epilepsy. Exp Anim. 64(1):1-7, 2015. "A rat model for LGI1-related epilepsies. Baulac S, Ishida S, Mashimo T, Boillot M, Fumoto N, Kuwamura M, Ohno Y, Takizawa A, Aoto T, Ueda M, Ikeda A, LeGuern E, Takahashi R, Serikawa T. Hum Mol Genet. 2012 Aug 15;21(16):3546-57. Additional strain information