The National BioResource Project for the Rat in Japan

Strain information

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NBRP Rat No: 0659
Strain name: F344.WIC-Tgrdw/Kts
Commmon Name: rdw rat, F344-rdw
Principal Investigator:
Sen-ichi FurudateSchool of Medicine, Kitasato University
Preservation Status:
Coat Color
Inbred Generations
F4
Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Genetic Status
Comercial Availability
Research Category
Gene Affected
rdw
Origin
Strain characteristics
Breeding Conditions
Genotyping
References
Shibayama K, Ohyama Y., Ono M. , Furudate S: Expression of mRNA coding for pituitary hormones and pituitary-specific transcription factor in the pituitary gland of the rdw rat with hereditary dwarfism. J. Endocrinol. 138: 307-313, 1993.
Ono M, Harigai T, Furudate S.: Pituitary-specific transcription factor Pit-1 in rdw rat with GH- and PRL- deficient dwarfism. J. Endocrinol. 143, 479-487, 1994.
Oh-Ishi M, Omori A, Kwon J-Y, Agui T, Maeda T, Furudate S: Detection and identification of proteins related to the hereditary dwarfism of the rdw rat. Endocrinology, 139 (3), 1288-1299, 1998.
Kim PS, Ding M, Menon S, Jung C-G, Cheng J-M, Miyamoto T, Li B, Furudate S , Agui T: A missence mutation G2320R in the thyroglobulin gene causes non-goitrous congenital primary hypothyroidism in the WIC-rdw rat. Mol Endocrinol 14 (12): 1944-1953, 2000
Hishinuma A, Furudate S, Oh-ishi M, Nagakubo N, Namatame T, Ieiri T: A novel missense mutation (G2320R) of the thyroglobulin gene causes hereditary hypothyroidism of the rdw rat. Endocrinology 141 (11): 4050-4055, 2000
Sakai Y., Yamashina S, Furudate S: Missing Secretory Granules, dilated Endoplasmic reticulum, and nuclear dislocation in the thyroid gland of rdw rats with hereditary dwarfism. Anat Rec 259: 60-66, 2000
Sakai Y, Yamashina S, Furudate S: Developmental delay and unstable state of the testes in the rdw rat with congenital hypothyroidism. Develop Growth Differ 46: 327-334, 2004.
Baryshev M, Sargsyan E, Wallin G, Lejnieks A, Furudate S, Hishinuma A, Mkrtchian   S: Unfolded protein response is involved in the pathology of human congenital hypothyroid goiter and rat non-goitrous congenital hypothyroidism. J Mol Endocrinol 32(3): 903-920, 2004
Oh-Nishi M, Saji M, Furudate S, Suzuki N: Dopamine D2-like receptor function is converted from excitatory to inhibitory by thyroxine in early development of hippocampus. J Neuroendocrinol 17(12), 836-845, 2005.
Furudate S, Ono M, Shibayama K, Ohyama Y, Kuwada M, Kimura Y, Kamaya T: Rescue from dwarfism by thyroid function conpensation in rdw rats. Exp Anim 54 (5), 455-460. 2005
Menon S, Lee J, Abplanalp WA, Yoo S-E, Agui T, Furudate S, Kim PS, Arvan P: Oxidoreductase interactions include a role for ERp72 engagement with mutant thyroglobulin from the rdw/rdw rat dwarf. J Bio Chem 282(9):6183-91. 2007
Oh-Ishi M, Kodera Y, Furudate S, Maeda T: Disease proteomics of endocrine disorders revealed by two-dimensional gel electrophoresis and mass spectrometry. Proteomics Clin Appl 2008 2: 327-337.
Additional strain information (Japanese only)