Strain information
 NBRP Rat No: 0659  Strain name: F344.WIC-Tgrdw/Kts  Commmon Name: rdw rat, F344-rdw Rat Genome Database
Principal Investigator:  Sen-ichi Furudate  School of Medicine, Kitasato University       1-15-1, Kitasato, Sagamihara    228-8555 Kanagawa     Japan
Tel: 042-778-9319    Fax: 042-778-7555 Email: furudate@med.kitasato-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  
Inbred Generations  F4
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected rdw
Origin
Strain characteristics
Breeding Conditions
Genotyping
References Shibayama K, Ohyama Y., Ono M. , Furudate S: Expression of mRNA coding for pituitary hormones and pituitary-specific transcription factor in the pituitary gland of the rdw rat with hereditary dwarfism. J. Endocrinol. 138: 307-313, 1993.
Ono M, Harigai T, Furudate S.: Pituitary-specific transcription factor Pit-1 in rdw rat with GH- and PRL- deficient dwarfism. J. Endocrinol. 143, 479-487, 1994.
Oh-Ishi M, Omori A, Kwon J-Y, Agui T, Maeda T, Furudate S: Detection and identification of proteins related to the hereditary dwarfism of the rdw rat. Endocrinology, 139 (3), 1288-1299, 1998.
Kim PS, Ding M, Menon S, Jung C-G, Cheng J-M, Miyamoto T, Li B, Furudate S , Agui T: A missence mutation G2320R in the thyroglobulin gene causes non-goitrous congenital primary hypothyroidism in the WIC-rdw rat. Mol Endocrinol 14 (12): 1944-1953, 2000
Hishinuma A, Furudate S, Oh-ishi M, Nagakubo N, Namatame T, Ieiri T: A novel missense mutation (G2320R) of the thyroglobulin gene causes hereditary hypothyroidism of the rdw rat. Endocrinology 141 (11): 4050-4055, 2000
Sakai Y., Yamashina S, Furudate S: Missing Secretory Granules, dilated Endoplasmic reticulum, and nuclear dislocation in the thyroid gland of rdw rats with hereditary dwarfism. Anat Rec 259: 60-66, 2000
Sakai Y, Yamashina S, Furudate S: Developmental delay and unstable state of the testes in the rdw rat with congenital hypothyroidism. Develop Growth Differ 46: 327-334, 2004.
Baryshev M, Sargsyan E, Wallin G, Lejnieks A, Furudate S, Hishinuma A, Mkrtchian 　　S: Unfolded protein response is involved in the pathology of human congenital hypothyroid goiter and rat non-goitrous congenital hypothyroidism. J Mol Endocrinol 32(3): 903-920, 2004
Oh-Nishi M, Saji M, Furudate S, Suzuki N: Dopamine D2-like receptor function is converted from excitatory to inhibitory by thyroxine in early development of hippocampus. J Neuroendocrinol 17(12), 836-845, 2005.
Furudate S, Ono M, Shibayama K, Ohyama Y, Kuwada M, Kimura Y, Kamaya T: Rescue from dwarfism by thyroid function conpensation in rdw rats. Exp Anim 54 (5), 455-460. 2005
Menon S, Lee J, Abplanalp WA, Yoo S-E, Agui T, Furudate S, Kim PS, Arvan P: Oxidoreductase interactions include a role for ERp72 engagement with mutant thyroglobulin from the rdw/rdw rat dwarf. J Bio Chem 282(9):6183-91. 2007
Oh-Ishi M, Kodera Y, Furudate S, Maeda T: Disease proteomics of endocrine disorders revealed by two-dimensional gel electrophoresis and mass spectrometry. Proteomics Clin Appl 2008 2: 327-337.
Additional strain information