Strain information
 NBRP Rat No: 0665  Strain name: UPL/CasTakeu  Commmon Name: UPL Rat Genome Database
Principal Investigator:  Noriko Takeuchi  Meijo University       150 Yagotoyama, Tenpaku-ku, Nagoya-shi, Aichi    468-8503 Nagoya-shi     Japan
Tel: 052-839-2684    Fax: 052-834-8090 Email: ntakeuch@meijo-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  albino（ｃ）
Inbred Generations   F?+1+9 (Murch 20112)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Gja8: gap junction membrane channel protein alpha 8
Origin This mutant strain showing hereditary cataract was detected in Sprague-Dawley rat colony.
Strain characteristics Homozygous rats show early-onset cataract and heterozygous rats show late-onset cataract. A candidate gene for formation of cataracts in UPL rats was mapped to rat chr 2, and the missense mutation （R340W） in connexin 50 (Cx50/Gja8) gene was a strong candidate.
Breeding Conditions
Genotyping
References Tomohiro M, Maruyama Y, Yazawa K, Shinzawa S, Mizuno A.
The UPL rat: a new model for hereditary cataracts with two cataract formation types.
Exp Eye Res. 1993 Oct;57(4):507-10.

Tomohiro M, Aida Y, Inomata M, Ito Y, Mizuno A, Sakuma S.
Immunohistochemical study of calpain-mediated alpha-crystallin proteolysis in the UPL rat hereditary cataract.
Jpn J Ophthalmol. 1997 May-Jun;41(3):121-9.

Nabekura T, Koizumi Y, Nakao M, Tomohiro M, Inomata M, Ito Y.
Delay of cataract development in hereditary cataract UPL rats by disulfiram and aminoguanidine.
Exp Eye Res. 2003 Feb;76(2):169-74.

Nabekura T, Tomohiro M, Ito Y, Kitagawa S.
Changes in plasma membrane Ca2+ -ATPase expression and ATP content in lenses of hereditary cataract UPL rats.
Toxicology. 2004 Apr 15;197(2):177-83.

Nagai N, Ito Y.
Adverse effects of excessive nitric oxide on cytochrome c oxidase in lenses of hereditary cataract UPL rats.
Toxicology. 2007 Dec 5;242(1-3):7-15. Epub 2007 Sep 8.

Nagai N, Ito Y, Okamura H.
Involvement of interleukin 18 in cataract development in hereditary cataract UPL rats.
J Biochem. 2007 Nov;142(5):597-603.

Nagai N, Ito Y, Takeuchi N, Usui S, Hirano K.
Comparison of the mechanisms of cataract development involving differences in Ca2+ regulation in lenses among three hereditary cataract model rats.
Biol Pharm Bull. 2008 Nov;31(11):1990-5.
Additional strain information