NBRP Rat No: 0668 |
Strain name: F344-Sv2am1Kyo |
Commmon Name: |
Rat Genome Database |
Principal Investigator: |
Tadao Serikawa Graduate School of Medicine, Kyoto University Yoshidakonoe-cho, Sakyo-ku 606-8501 Kyoto JAPAN |
Tel: 075-753-4360 Fax: 075-753-4409 |
Email: serikawa@anim.med.kyoto-u.ac.jp |
Preservation Status: |
Embryo Sperm Living Animals |
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Coat Color |
albino (c) |
Inbred Generations |
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Usage Restrictions |
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. |
Genetic Status |
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Comercial Availability |
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Research Category |
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Gene Affected |
Sv2a : synaptic vesicle glycoprotein 2a |
Origin |
Established by ENU mutagenesis (gene-driven). This strain has misssense mutation (L174Q)in Sv2a gene. |
Strain characteristics |
Sv2aL174Q(F344-Sv2am1Kyo) is a novel rat model carrying the missense mutation (L174Q) in the Sv2a gene encoding the synaptic vesicle glycoprotein 2A. Sv2aL174Q rats show normal appearance and grow well, however, they are sensitive to seizure induction by pentylenetetrazole (PTZ, GABAA antagonist). Sv2aL174Q rats are also very susceptible to the kindling development induced by repeated treatment with PTZ or electrical stimulation of the amygdala. Neurochemical studies reveal that depolarization-evoked synaptic GABA release is impaired in the hippocampus and amygdala of Sv2aL174Q rats. |
Breeding Conditions |
Good breeding performance |
Genotyping |
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References |
Ohno Y, Tokudome K
Therapeutic role of synaptic vesicle glycoprotein 2A (SV2A) in modulating epileptogenesis.
CNS Neurol. Disord. Drug Targets, 16:463-471, 2017
Tokudome K, Okumura T, Terada R, Shimizu S, Kunisawa N, Mashimo T, Serikawa T, Sasa M, Ohno Y.
A Missense Mutation of the Gene Encoding Synaptic Vesicle Glycoprotein 2A (SV2A) Confers Seizure Susceptibility by Disrupting Amygdalar Synaptic GABA Release.
Front Pharmacol. 2016 Jul 14;7:210.
Tokudome K, Okumura T, Shimizu S, Mashimo T, Takizawa A, Serikawa T, Terada R, Ishihara S, Kunisawa N, Sasa M, Ohno Y.
Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission.
Sci Rep. 2016 Jun 6;6:27420. |
Additional strain information |
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