NBRP Rat No: 0668
Rat Genome Database
Tadao Serikawa Graduate School of Medicine, Kyoto University Yoshidakonoe-cho, Sakyo-ku 606-8501 Kyoto JAPAN
Tel: 075-753-4360 Fax: 075-753-4409
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Research Area Others
Sv2a : synaptic vesicle glycoprotein 2a
Established by ENU mutagenesis (gene-driven). This strain has misssense mutation （L174Q）in Sv2a gene.
Sv2aL174Q（F344-Sv2am1Kyo） is a novel rat model carrying the missense mutation (L174Q) in the Sv2a gene encoding the synaptic vesicle glycoprotein 2A. Sv2aL174Q rats show normal appearance and grow well, however, they are sensitive to seizure induction by pentylenetetrazole (PTZ, GABAA antagonist). Sv2aL174Q rats are also very susceptible to the kindling development induced by repeated treatment with PTZ or electrical stimulation of the amygdala. Neurochemical studies reveal that depolarization-evoked synaptic GABA release is impaired in the hippocampus and amygdala of Sv2aL174Q rats.
Good breeding performance
Ohno Y, Tokudome K
Therapeutic role of synaptic vesicle glycoprotein 2A (SV2A) in modulating epileptogenesis.
CNS Neurol. Disord. Drug Targets, 16:463-471, 2017
Tokudome K, Okumura T, Terada R, Shimizu S, Kunisawa N, Mashimo T, Serikawa T, Sasa M, Ohno Y.
A Missense Mutation of the Gene Encoding Synaptic Vesicle Glycoprotein 2A (SV2A) Confers Seizure Susceptibility by Disrupting Amygdalar Synaptic GABA Release.
Front Pharmacol. 2016 Jul 14;7:210.
Tokudome K, Okumura T, Shimizu S, Mashimo T, Takizawa A, Serikawa T, Terada R, Ishihara S, Kunisawa N, Sasa M, Ohno Y.
Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission.
Sci Rep. 2016 Jun 6;6:27420.
Additional strain information