Strain information
NBRP Rat No: 0669
Strain name
: F344.Cg-
Du Tyr
C
/Kyo
Commmon Name: downunder rat
Rat Genome Database
Principal Investigator:
Takashi Kuramoto Graduate School of Medicine, Kyoto University Yoshidakonoe-cho, Sakyo-ku 606-8501 Kyoto Japan
Tel: 075-753-4494 Fax: 075-753-4409
Email: kuramot@anim.med.kyoto-u.ac.jp
Preservation Status:
Embryo
Sperm
Living Animals
Coat Color
downunder
Inbred Generations
N8F2
Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
This strain with Downunder (Du) mutation is originated from a male fancy rat (Coming Home. This rat was introduced from U.S.A. on July 13th, 2005.). F1 generation was obtained by crossing with TM/Kyo female. A F3 male rat (#313) was crossed with WTC/Kyo and we obtained F3+1 (18/10/2006). The sperms were collected from a F3+4 rat.
Strain characteristics
Heterozygous rats (downunder rat) have patchy pattern on their back and the same pattern is also obserbe on their abdominal skin hair. This rare hair color pattern is observed when they have a hooded mutation. This phenotype is dominant inheritance and homozygous rats are embryonic lethal.
Breeding Conditions
maintained by crossing between Du/+ (downunder) and +/+ (hooded). Tyrosinase allele: C/C
Genotyping
The causative gene is unknown.
References
Genetic analyses of fancy rat-derived mutations.
Kuramoto T, Yokoe M, Yagasaki K, Kawaguchi T, Kumafuji K, Serikawa T.
Exp Anim. 2010;59(2):147-55.
Additional strain information