Strain information

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NBRP Rat No: 0077

Strain name: WKAH.LEC-Ptprk^thid/Tj

Commmon Name: WKAH.C-thid

Rat Genome Database

Principal Investigator:

Kozo MatsumotoThe University of Tokushima Graduate School of Medicine

Preservation Status:

Embryo Sperm Living Animals

Coat Color

Inbred Generations

N8F41

Usage Restrictions

The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT must agree on collaborative research with the DEPOSITOR. Any form of publications of data resulting from the use of the BIOROGICAL RESOURCE require co-authorship. This condition is NOT limited to two-year period after deposition.

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Ptprk: protein tyrosine phosphatase, receptor type, K, extracellular region

Origin

A congenic strain produced by 8 generation backcrosses to WKAH strain in 1989.

Strain characteristics

a defect of T cell maturation

Breeding Conditions

Good breeding performance.

Genotyping

References

Chai JG, Sakai T, Hisaeda H, Nagasawa H, Yasutomo K, Furukawa A, Ishikawa H, Maekawa Y, Uehara H, Izumi K, Matsumoto K, Himeno K.
Development of functional rat-derived T cells in SCID mice engrafted with the fetal thymus of LEC rats which are defective in CD4+ T cells.
Microbiol Immunol. 1996;40(9):659-64.

Additional strain information (Japanese only)

WKAH