Strain information

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NBRP Rat No: 0707

Strain name: SHR.SHRSP-(D1Rat93-D1Rat269)(D18Rat73-D18Rat11)/Izm

Commmon Name: SHRpch1_18

Rat Genome Database

Principal Investigator:

Tohru NabikaShimane University, School of Medicine

Preservation Status:

Embryo Sperm Living Animals

Coat Color

白

Inbred Generations

F11

Usage Restrictions

Recipients are requested to obtain a written approval of the depositor.

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Origin

A double congenic strain made by introducing segments of chromosome 1 and 18 from SHRSP/Izm into SHR/Izm.

Strain characteristics

Hypertension (as severe as SHR rat) This rat develops a stroke caused by salt loading at an early stage.

Breeding Conditions

Genotyping

References

Yamagata K, Yamamoto M, Kawakami K, Ohara H, Nabika T.
Arginine vasopressin regulated ASCT1 expression in astrocytes from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats.
Neuroscience. 267:277-285, 2014.

Additional strain information (Japanese only)