NBRP Rat No: 0694
Commmon Name: XSCID-TALEN
Rat Genome Database
Tomoji Mashimo The University of Tokyo, The Institute of Medical Science 4-6-1 Shirokanedai-Minatoku-Tokyoto 108-8639 Japan
Tel: 03-6409-2489 Fax:
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Research Area Others 再生医療
interleukin 2 receptor gamma (Il2rg)
The strain having a Endonuclease-induced mutation in Il2rg gene was established by TAL effector nuclease obtained from Dr. Yamamoto at Hiroshima University.
This strain shows severe combined immunodeficiency caused by a 7-bp deletion in the exon 2 of Il2rg gene.
Rigatti LH, Toptan T, Newsome JT, Moore PS, Chang Y.
Identification and Characterization of Novel Rat Polyomavirus 2 in a Colony of X-SCID Rats by P-PIT assay.
mSphere. 2016 Dec 21;1(6). pii: e00334-16.
Sakuma T, Ochiai H, Kaneko T, Mashimo T, Tokumasu D, Sakane Y, Suzuki K, Miyamoto T, Sakamoto N, Matsuura S, Yamamoto T.
Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity.
Sci Rep. 2013 Nov 29;3:3379.
Additional strain information