Strain information  NBRP Rat No: 0694  Strain name: F344-Il2rgem7Kyo  Commmon Name: XSCID-TALEN Rat Genome Database Principal Investigator:  Tomoji Mashimo  The University of Tokyo, The Institute of Medical Science       4-6-1 Shirokanedai-Minatoku-Tokyoto    108-8639      Japan Tel: 03-6409-2489    Fax:  Email: mashimo@ims.u-tokyo.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  G1 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others 再生医療  Control Strain  Marker Strain Gene Affected interleukin 2 receptor gamma (Il2rg) Origin The strain having a Endonuclease-induced mutation in Il2rg gene was established by TAL effector nuclease obtained from Dr. Yamamoto at Hiroshima University. Strain characteristics This strain shows severe combined immunodeficiency caused by a 7-bp deletion in the exon 2 of Il2rg gene. Breeding Conditions Genotyping References Mizuno-Iijima S, Kawamoto S, Asano M, Mashimo T, Wakana S, Nakamura K, Nishijima KI, Okamoto H, Saito K, Yoshina S, Miwa Y, Nakamura Y, Ohkuma M, Yoshiki A. Mammalian genome research resources available from the National BioResource Project in Japan. Mamm Genome. 2024 Dec;35(4):497-523. Tadokoro T, Murata S, Kato M, Ueno Y, Tsuchida T, Okumura A, Kuse Y, Konno T, Uchida Y, Yamakawa Y, Zushi M, Yajima M, Kobayashi T, Hasegawa S, Kawakatsu-Hatada Y, Hayashi Y, Osakabe S, Maeda T, Kimura K, Mori A, Tanaka M, Kamishibahara Y, Matsuo M, Nie YZ, Okamoto S, Oba T, Tanimizu N, Taniguchi H. Human iPSC-liver organoid transplantation reduces fibrosis through immunomodulation. Sci Transl Med. 2024 Jul 24;16(757):eadg0338. Shinji Kawaguchi, Yusuke Soma, Kazuaki Nakajima, Hideaki Kanazawa, Shugo Tohyama, Ryota Tabei, Akinori Hirano, Noriko Handa, Yoshitake Yamada, Shigeo Okuda, Shuji Hishikawa, Takumi Teratani, Satoshi Kunita, Yoshikazu Kishino, Marina Okada, Sho Tanosaki, Shota Someya, Yuika Morita, Hidenori Tani, Yujiro Kawai, Masataka Yamazaki, Akira Ito, Rei Shibata, Toyoaki Murohara, Yasuhiko Tabata, Eiji Kobayashi, Hideyuki Shimizu, Keiichi Fukuda, Jun Fujita Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals JACC Basic Transl Sci. 2021 Feb 19;6(3):239-254. Tanaka M, Kuramochi M, Nakanishi S, Kuwamura M, Kuramoto T. Rat polyomavirus 2 infection in a colony of X-linked severe combined immunodeficiency rats in Japan. J Vet Med Sci. 2018 Sep 13;80(9):1400-1406. Matsuoka AJ, Sayed ZA, Stephanopoulos N, Berns EJ, Wadhwani AR, Morrissey ZD, Chadly DM, Kobayashi S, Edelbrock AN, Mashimo T, Miller CA, McGuire TL, Stupp SI, Kessler JA. Creating a stem cell niche in the inner ear using self-assembling peptide amphiphiles. PLoS One. 2017 Dec 28;12(12):e0190150. Rigatti LH, Toptan T, Newsome JT, Moore PS, Chang Y. Identification and Characterization of Novel Rat Polyomavirus 2 in a Colony of X-SCID Rats by P-PIT assay. mSphere. 2016 Dec 21;1(6). pii: e00334-16. Sakuma T, Ochiai H, Kaneko T, Mashimo T, Tokumasu D, Sakane Y, Suzuki K, Miyamoto T, Sakamoto N, Matsuura S, Yamamoto T. Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity. Sci Rep. 2013 Nov 29;3:3379. Additional strain information