Strain information
 NBRP Rat No: 0078  Strain name: DRH/Seac  Commmon Name: Rat Genome Database
Principal Investigator:  Masaki Takeuchi  Seac Yoshitomi, LTD       955 Koiwai Yoshitomi-cho, Chikujo-gun    871-8550 Fukuoka     JAPAN
Tel: 0979-22-9577    Fax: 0979-24-1955 Email: Takeuchi.Masaki@me.m-pharma.co.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/DRH/a%20(Large).jpg ../images/Photos/DRH/o%20(Large).jpg
Coat Color  albino (c)
Inbred Generations  F41+?+33(March 2012)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin DRH was established by selective mating of the 3'-Me-DAB resistant progeny of closed colony Donryu rats at Osaka University in 1981. Introduced to Seac Yoshitomi, LTD. in 1991.
Strain characteristics Resistant to carcinoma.
Breeding Conditions
Genotyping Biochemical gene test and immunological gene test
References Higashi K, Denda A, Higashi T, Hiai H.
Genetic resistance to chemical hepatocarcinogenesis in the DRH rat strain.
Comparative Medicine 54(4):373-377, 2004.

Liu H, Higashi K, Hiai H.
Role of resistant Drh1 locus in chemical carcinogen-induced hepatocarcinogenesis in rats: analysis with a speed congenic strain.
Cancer Sci. 2005 Mar;96(3):164-9.

Hiai H, Liu H, Omi N, Tanuma J, Higashi K.
DRH strain rats: Genetic resistance to chemical hepatocarcinogenesis.
Trends in Cancer Research 2: 127-134, 2006.

Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H.
AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats.
Biochem Biophys Res Commun. 2013 Dec 13. pii: S0006-291X(13)02128-1.
Additional strain information DRH