Origin
DRH was established by selective mating of the 3'-Me-DAB resistant progeny of closed colony Donryu rats at Osaka University in 1981. Introduced to Seac Yoshitomi, LTD. in 1991.
Genotyping
Biochemical gene test and immunological gene test
References
Higashi K, Denda A, Higashi T, Hiai H.
Genetic resistance to chemical hepatocarcinogenesis in the DRH rat strain.
Comparative Medicine 54(4):373-377, 2004.
Liu H, Higashi K, Hiai H.
Role of resistant Drh1 locus in chemical carcinogen-induced hepatocarcinogenesis in rats: analysis with a speed congenic strain.
Cancer Sci. 2005 Mar;96(3):164-9.
Hiai H, Liu H, Omi N, Tanuma J, Higashi K.
DRH strain rats: Genetic resistance to chemical hepatocarcinogenesis.
Trends in Cancer Research 2: 127-134, 2006.
Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H.
AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats.
Biochem Biophys Res Commun. 2013 Dec 13. pii: S0006-291X(13)02128-1.