Strain information
 NBRP Rat No: 0697  Strain name: DA.ACI-(D10Rat2-D10Rat29)/Kini  Commmon Name: DA.ACI-Eae18 Rat Genome Database
Principal Investigator:  Tomas Olsson  Karolinska Institutet       CMM, Karolinska University Hospital, 171 76,     L8:04, Stockholm     Sweden
Tel: +46 8 51776258    Fax: +46 8 51775562 Email: tomas.olsson@ki.se
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/ ../images/Photos/
Coat Color  Agouti
Inbred Generations  Congenic strain was establiesh using a “speed congenic” strategy as N6F1 in 1999. Since then, the strain was kept as inbred.
Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Development and the characterization of the strain has been published in this article:
Jagodic M, Kornek B, Weissert R, Lassmann H, Olsson T, Dahlman I. Congenic mapping confirms a locus on rat chromosome 10 conferring strong protection against myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.Immunogenetics. 2001 Jul;53(5):410-5. PMID: 11486278.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected > 50 Mb
Origin Inbred Dark Agouti (DA) rats originally obtained from Zentralinstitut for Versuchstierzucht (Hannover, Germany) and AxC 9935 Irish (ACI) rats from Harlan Sprague Dawley Inc. (Indianapolis, USA). Congenic strain was establiesh using a “speed congenic” strategy (Wakeland et al. 1997) with 8 microsatellite markers from the telomeric marker D10Rat2 to D10Rat29, and 70 microsatellite markers outside the congenic regions. In the N5 generation, all 70 background markers were fixed as DA homozygous. One further backcross was performed and chromosome 10 heterozygous rats subsequently intercrossed to produce the congenic strain DA.ACI (N6F1) in 1999. Since then, the strain was kept as inbred.
Strain characteristics Partial protection against experimental autoimmune encephalomyelitis (EAE) compared to the susceptible parental DA strain.
Breeding Conditions Good breeding performance.
Genotyping Flanking markers inside the congenic fragment: D10Rat2 and D10Rat29.
References Jagodic M, Kornek B, Weissert R, Lassmann H, Olsson T, Dahlman I. Congenic mapping confirms a locus on rat chromosome 10 conferring strong protection against myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.Immunogenetics. 2001 Jul;53(5):410-5. PMID: 11486278.
Additional strain information