Strain information
 NBRP Rat No: 0701  Strain name: DA.PVG.1AV1-(D4Kini3-D4Mgh14)/Kini  Commmon Name: DA.PVG.1AV1-Hse1-R1 Rat Genome Database
Principal Investigator:  Tomas Olsson  Karolinska Institutet       CMM, Karolinska University Hospital, 171 76,     L8:04, Stockholm     Sweden
Tel: +46 8 51776258    Fax: +46 8 51775562 Email: tomas.olsson@ki.se
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/ ../images/Photos/
Coat Color  Agouti
Inbred Generations  Congenic strain was establiesh using a “speed congenic” strategy as N5F1 in 2009. Since then, the strain was kept as inbred.
Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Development and the characterization of the strain has been published in this article:
Abdelmagid N, Bereczky-Veress B, Guerreiro-Cacais AO, Bergman P, Luhr KM, Bergström T, Sköldenberg B, Piehl F, Olsson T, Diez M. The Calcitonin Receptor Gene Is a Candidate for Regulation of Susceptibility to Herpes simplex Type 1 Neuronal Infection Leading to Encephalitis in Rat. PLoS Pathog. 2012 Jun;8(6):e1002753. Epub 2012 Jun 28. PMID: 22761571.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others Viral encephalitis (HSE)
 Control Strain  Marker Strain
Gene Affected > 9Mb
Origin Inbred Dark Agouti (DA) rats were originally obtained from the Zentralinstitut für Versuchstierzucht (Hannover, Germany) and Piebald Virol Glaxo(PVG) rats from Harlan UK Limited (Blackthorn, UK). The congenic line was established from DA and MHC-identical PVG.A rats using a speed-congenic approach with marker assisted selection. DA females were mated with male offspring selected from F2 (DAxPVG.A) with heterozygote alleles within chromosome 4 and Hse1 QTL interval and against lower PVG.A background contamination using 86 microsatellite markers equally spaced throughout the genome (at 20 centimorgan cM intervals). A breeding pair selected from the N5 generation were crossed for two generations to produce homozygous DA.PVGc4-Hse1-R1 congenic rats, carrying PVG alleles between D4Kini3 at 27.81 Mb and D4Mgh14 at 36.5 Mb.
Strain characteristics Protected from Herpes Simplex Encephalitis (HSE) development in 45 days old rats.
Breeding Conditions Good breeding performance.
Genotyping Flanking markers inside the congenic fragment: D4Kini3 - D4Mgh14.
References Abdelmagid N, Bereczky-Veress B, Guerreiro-Cacais AO, Bergman P, Luhr KM, Bergström T, Sköldenberg B, Piehl F, Olsson T, Diez M. The Calcitonin Receptor Gene Is a Candidate for Regulation of Susceptibility to Herpes simplex Type 1 Neuronal Infection Leading to Encephalitis in Rat. PLoS Pathog. 2012 Jun;8(6):e1002753. Epub 2012 Jun 28. PMID: 22761571.
Additional strain information