NBRP Rat No: 0700 |
Strain name: DA.PVG.1AV1-(D10Got6-D10Rat184)/Kini |
Commmon Name: DA.PVG.1AV1-Vra4 |
Rat Genome Database |
Principal Investigator: |
Tomas Olsson Karolinska Institutet CMM, Karolinska University Hospital, 171 76, L8:04, Stockholm Sweden |
Tel: +46 8 51776258 Fax: +46 8 51775562 |
Email: tomas.olsson@ki.se |
Preservation Status: |
Embryo Sperm Living Animals |
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Coat Color |
Agouti |
Inbred Generations |
Congenic strain was established by transfer of the Vra4 segment andvanced intercross line DAxPVG.AV1 and backcrossed for 9 generetaion before kept as inbread. |
Usage Restrictions |
In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested. Development and the characterization of the strain has been published in this article: Harnesk K, Swanberg M, Öckinger J, Diez M, Lidman O, Wallström E, Lobell A, Olsson T, Piehl F. Vra4 congenic rats with allelic differences in the class II transactivator gene display altered susceptibility to experimental autoimmune encephalomyelitis. J Immunology. 2008 PMID:18292553 |
Genetic Status |
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Comercial Availability |
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Research Category |
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Gene Affected |
10,5Mb (positionally cloned to CIITA gene) |
Origin |
Inbred Dark Agouti (DA) rats were originally obtained from
the Zetralinstitut für Versuchstierzucht (Hanover,
Germany) and Piebald Virol Glaxo (PVG) from Harlan UK
Limited (Blackthorn, UK). Congenic strain was established by transfer of the defined Vra4 segment selected from male donors of G8 generation of a DAxPVG1.AV1 andvanced intercross line. Subsequential backcrossing
for 9 generations. |
Strain characteristics |
Lower expression of MHC class II on B cells, milder disease course due to EAE compared to DA. |
Breeding Conditions |
Good breeding performances. |
Genotyping |
Flanking marker inside the congenic fragment: D10Got6 and D10Rat184. |
References |
Harnesk K, Swanberg M, Öckinger J, Diez M, Lidman O, Wallström E, Lobell A, Olsson T, Piehl F. Vra4 congenic rats with allelic differences in the class II transactivator gene display altered susceptibility to experimental autoimmune encephalomyelitis. J Immunology. 2008 PMID:18292553 |
Additional strain information |
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