Strain information
 NBRP Rat No: 0700  Strain name: DA.PVG.1AV1-(D10Got6-D10Rat184)/Kini  Commmon Name: DA.PVG.1AV1-Vra4 Rat Genome Database
Principal Investigator:  Tomas Olsson  Karolinska Institutet       CMM, Karolinska University Hospital, 171 76,     L8:04, Stockholm     Sweden
Tel: +46 8 51776258    Fax: +46 8 51775562 Email: tomas.olsson@ki.se
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/ ../images/Photos/
Coat Color  Agouti
Inbred Generations  Congenic strain was established by transfer of the Vra4 segment andvanced intercross line DAxPVG.AV1 and backcrossed for 9 generetaion before kept as inbread.
Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Development and the characterization of the strain has been published in this article:
Harnesk K, Swanberg M, Öckinger J, Diez M, Lidman O, Wallström E, Lobell A, Olsson T, Piehl F. Vra4 congenic rats with allelic differences in the class II transactivator gene display altered susceptibility to experimental autoimmune encephalomyelitis. J Immunology. 2008 PMID:18292553
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected 10,5Mb (positionally cloned to CIITA gene)
Origin Inbred Dark Agouti (DA) rats were originally obtained from the Zetralinstitut für Versuchstierzucht (Hanover, Germany) and Piebald Virol Glaxo (PVG) from Harlan UK Limited (Blackthorn, UK). Congenic strain was established by transfer of the defined Vra4 segment selected from male donors of G8 generation of a DAxPVG1.AV1 andvanced intercross line. Subsequential backcrossing for 9 generations.
Strain characteristics Lower expression of MHC class II on B cells, milder disease course due to EAE compared to DA.
Breeding Conditions Good breeding performances.
Genotyping Flanking marker inside the congenic fragment: D10Got6 and D10Rat184.
References Harnesk K, Swanberg M, Öckinger J, Diez M, Lidman O, Wallström E, Lobell A, Olsson T, Piehl F. Vra4 congenic rats with allelic differences in the class II transactivator gene display altered susceptibility to experimental autoimmune encephalomyelitis. J Immunology. 2008 PMID:18292553
Additional strain information