Strain information
 NBRP Rat No: 0699  Strain name: DA.PVG.1AV1-(D4Rat107-D4Got132)/Kini  Commmon Name: DA.PVG.1AV1-Eae20 Rat Genome Database
Principal Investigator:  Tomas Olsson  Karolinska Institutet       CMM, Karolinska University Hospital, 171 76,     L8:04, Stockholm     Sweden
Tel: +46 8 51776258    Fax: +46 8 51775562 Email: tomas.olsson@ki.se
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/ ../images/Photos/
Coat Color  Agouti
Inbred Generations  Congenic strain was establiesh using a conventional congenic strategy with more than 13 backcross generations in 2005. Since then, the strain was kept as inbred.
Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Development and the characterization of the strain has been published in this article:
Maja Jagodic, Monica Marta, Kristina Becanovic, Jian Rong Sheng, Rita Nohra, Tomas Olsson and Johnny C. Lorentzen. Resolution of a 16.8-Mb Autoimmunity-Regulating Rat Chromosome 4 Region into Multiple Encephalomyelitis Quantitative Trait Loci and Evidence for Epistasis; J Immunol 2005; 174:918-924. PMID: 15634914
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected > 8Mb
Origin Inbred Dark Agouti (DA) rats were originally obtained from the Zentralinstitut für Versuchstierzucht (Hannover, Germany) and Piebald Virol Glaxo(PVG) rats from Harlan UK Limited (Blackthorn, UK). Congenic strain was established by selective transferring of PVG alleles in the interval between D4Rat137 and D4Kiru157 onto DA background in minimum of 13 backcross generations.
Strain characteristics Protection against experimental autoimmune encephalomyelitis (EAE) compared to the susceptible parental DA strain.
Breeding Conditions Good breeding performance.
Genotyping Flanking markers inside the congenic fragment: D4Rat107-D4Got132.
References Becanovic K, Bäckdahl L, Wallström E, Aboul-Enein F, Lassmann H, Olsson T, Lorentzen JC. Paradoxical effects of arthritis-regulating chromosome 4 regions on myelin oligodendrocyte glycoprotein-induced encephalomyelitis in congenic rats. Eur J Immunol. 2003 Jul;33(7):1907-16. PMID: 12811851.
Maja Jagodic, Monica Marta, Kristina Becanovic, Jian Rong Sheng, Rita Nohra, Tomas Olsson and Johnny C. Lorentzen. Resolution of a 16.8-Mb Autoimmunity-Regulating Rat Chromosome 4 Region into Multiple Encephalomyelitis Quantitative Trait Loci and Evidence for Epistasis; J Immunol 2005; 174:918-924. PMID: 15634914
Additional strain information