Strain information  NBRP Rat No: 0722  Strain name: SD-Pax6Sey2/Mce  Commmon Name: Rat Genome Database Principal Investigator:  Sachiko Iseki  Tokyo Medical and Dental University       1-5-45, Yushima, Bunkyo-ku    113-8549      Japan Tel: 03-5803-5579    Fax: 03-5803-0213 Email: s.iseki.emb@tmd.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  白 Inbred Generations  F15 Usage Restrictions  The recipient is requested to cite the literature designated by the DEPOSITOR. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Pax6 Origin This rat (developed spontaneous microphthalmia) was found in a SD rat colony at Yamanouchi Pharma Inc. (Astellas Pharma Inc.). Strain characteristics homozygous rats: embryonic lethality heterozygous rats: microphthalmia Breeding Conditions Mating between heterozygous rats. heterozygous rats is identified by microphthalmia. Genotyping Pax6AS CTTGCGTGGGTTGCCCTGGTA Pax6S GTGTCATCAATAAACAGAGTTCTTC References Osumi N, Hirota A, Ohuchi H, Nakafuku M, Iimura T, Kuratani S, Fujiwara M, Noji S, Eto K.:Pax-6 is involved in the specification of hindbrain motor neuron subtype.Development.124(15):2961-2972,1997. Additional strain information