Strain information  NBRP Rat No: 0080  Strain name: PVG/Seac  Commmon Name: Piebald Virol Glaxo Rat Genome Database Principal Investigator:  Masaki Takeuchi  Seac Yoshitomi, LTD       955 Koiwai Yoshitomi-cho, Chikujo-gun    871-8550 Fukuoka     JAPAN Tel: 0979-22-9577    Fax: 0979-24-1955 Email: Takeuchi.Masaki@me.m-pharma.co.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  black-hooded (a,B,C,h) Inbred Generations  F27+32 (April 2012) Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin Harlan Olac > Seac Yoshitomi, LTD (1990) Strain characteristics It is used as a donor or recipient in organ transplant experiments. It is also used as an adjuvant arthritis model. Breeding Conditions Genotyping biochemical genetic examination and immunological genetic examination References Sung SY, Lin YW, Wu CC, Lin CY, Hsu PS, Periasamy S, Nagarajan B, Hsieh DJ, Tsai YT, Tsai CS, Lin FY. Supercritical carbon dioxide-decellularized arteries exhibit physiologic-like vessel regeneration following xenotransplantation in rats. Biomater Sci. 2023 Mar 28;11(7):2566-2580. Lin YW, Tsai CS, Huang CY, Tsai YT, Shih CM, Lin SJ, Li CY, Lin CY, Sung SY, Lin FY. Far-Infrared Therapy Decreases Orthotopic Allograft Transplantation Vasculopathy. Biomedicines. 2022 May 7;10(5):1089. Lin FY, Shih CM, Huang CY, Tsai YT, Loh SH, Li CY, Lin CY, Lin YW, Tsai CS. Dipeptidyl Peptidase-4 Inhibitor Decreases Allograft Vasculopathy Via Regulating the Functions of Endothelial Progenitor Cells in Normoglycemic Rats. Cardiovasc Drugs Ther. 2021 Dec;35(6):1111-1127. Yoshihara M, Saito D, Sato T, Ohara O, Kuramoto T, Suyama M. Design and application of a target capture sequencing of exons and conserved non-coding sequences for the rat. BMC Genomics. 2016 Aug 9;17:593. Yoshimi K, Kaneko T, Voigt B, Mashimo T. Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform. Nat Commun. 5:4240, 2014. Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H. AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats. Biochem Biophys Res Commun. 2013 Dec 13. pii: S0006-291X(13)02128-1. Nakano T, Lai CY, Goto S, Hsu LW, Kawamoto S, Ono K, Chen KD, Lin CC, Chiu KW, Wang CC, Cheng YF, Chen CL. Immunological and regenerative aspects of hepatic mast cells in liver allograft rejection and tolerance. PLoS One. 2012;7(5):e37202. Additional strain information PVG