Strain information
 NBRP Rat No: 0729  Strain name: LEW.WKY-(D13Arb15-D13Rat77)(D16Rat40-D16Rat88)/Tja  Commmon Name: LEW.WCrgn1,2 Rat Genome Database
Principal Investigator:  Timothy J. Aitman  Medical Research Council       Hammersmith Hospital campus, Du Cane Road    W12 0NN London    
Tel: +44 20 8383 4253    Fax: +44 20 8383 8577 Email: t.aitman@csc.mrc.ac.uk
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  Albino
Inbred Generations  
Usage Restrictions  The recipient is requested to cite the literature designated by the DEPOSITOR.

D'Souza Z., McAdoo S.P., Smoth J., Pusey C.D., Cook H.T., Behmoaras J., Aitman T.J. (2013) Experimental crescentic glomerulonephritis: a new bicongenic rat model. Disease Models and Mechanisms.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Lewis bicongenic (chromosomes 13 and 16)
Origin LEWIS: Lewis from Wistar stock, to Aptekman and Bogden 1954 at F20, to SIlvers 1958 at F31. Subsequently distributed by Silvers. WKY: Wistar stock from Kyoto School of Medicine to National Institutes of Health 1971.
Strain characteristics Development of glomerular crescents, a hallmark of crescentic glomerulonephritis (CRGN) after the induction of nephrotoxic serum in this Lewis-related bicongenic strain, compared to parental Lewis strain which is resistant to CRGN.
Breeding Conditions No special needs. Good breeding performance, 6-8 litters, normal diet, water acidification, no supplements, no medications.
Genotyping Microsatellite markers used for genotyping. Chromosome 13: Congenic locus spans between D13Arb15 to D13Rat77 Chromosome 16: Congenic locus spans between D16Rat40 to D16Rat88
References D'Souza et al (2013) Experimental crescentic glomerulonephritis: a new bicongenic rat model. Disease Models and Mechanisms.

Aitman et al (2006) Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature. 2006 Feb 16;439(7078):851-5.

Behmoaras et al (2008) Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility. Nat Genet. 2008 May;40(5):553-9. doi: 10.1038/ng.137.
Additional strain information