Strain information

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NBRP Rat No: 0081

Strain name: SHR.ODS-Gulo^od/Shi

Commmon Name: SHR.ODS-Gulo^od, SHR-od

Rat Genome Database

Principal Investigator:

Tsutomu HirasawaShionogi & Co., Ltd.

Preservation Status:

Embryo Sperm Living Animals

Coat Color

albino (c)

Inbred Generations

F36 (May 2009)

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Usage Restrictions

The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research with the DEPOSITOR.

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Gulo: gulonolactone (L-) oxidase

Origin

A congenic strain developed from a recipient, SHR(Spontaneously Hypertensive Rat) and a donor, ODS (Lack of L-gulono-gamma-lactone oxidasestrainin). Introduced to Nagoya University in 1995 (now F18).

Strain characteristics

The osteogenic disorder Shionogi (ODS) rat is a mutant Wistar rat that is subject to scurvy, because it lacks L-gulono-gamma-lactone oxidase, a key enzyme in L-ascorbic acid biosynthesis (Horio et al. 1985)

Breeding Conditions

Normal breeding when L-ascorbic acid is supplemented in food (1000mg/kg) or water (1g/L). Breeding performance is unclear post 3rd delivery.

Genotyping

PCR-RFLP

References

Horio F, Hayashi K, Mishima T, Takemori K, Oshima I, Makino S, Kakinuma A, Ito H.
A newly established strain of spontaneously hypertensive rat with a defect of ascorbic acid biosynthesis.
Life Sci. 2001 Sep 7;69(16):1879-90.

Kawai K, Ito H, Kubota H, Takemori K, Makino S, Horio F.
Changes in catecholamine metabolism by ascorbic acid deficiency in spontaneously hypertensive rats unable to synthesize ascorbic acid.
Life Sci. 2003 Feb 28;72(15):1717-32.

Additional strain information (Japanese only)

SHR