Strain information
 NBRP Rat No: 0081  Strain name: SHR.ODS-Gulood/Shi  Commmon Name: SHR.ODS-Gulood, SHR-od Rat Genome Database
Principal Investigator:  Tsutomu Hirasawa  Shionogi & Co., Ltd.        1405, Gotanda, Koka-cho, Koka-gun    520-3423 Shiga      JAPAN
Tel: 0748-88-3281    Fax: 0748-88-2783 Email: srp-contact@shionogi.co.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/SHR-od/471a%20(Large).jpg ../images/Photos/SHR-od/471z%20(Large).jpg
Coat Color  albino (c)
Inbred Generations  F36 (May 2009)
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research with the DEPOSITOR.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Gulo: gulonolactone (L-) oxidase
Origin A congenic strain developed from a recipient, SHR(Spontaneously Hypertensive Rat) and a donor, ODS (Lack of L-gulono-gamma-lactone oxidasestrainin). Introduced to Nagoya University in 1995 (now F18).
Strain characteristics The osteogenic disorder Shionogi (ODS) rat is a mutant Wistar rat that is subject to scurvy, because it lacks L-gulono-gamma-lactone oxidase, a key enzyme in L-ascorbic acid biosynthesis (Horio et al. 1985)
Breeding Conditions Normal breeding when L-ascorbic acid is supplemented in food (1000mg/kg) or water (1g/L). Breeding performance is unclear post 3rd delivery.
Genotyping PCR-RFLP
References Horio F, Hayashi K, Mishima T, Takemori K, Oshima I, Makino S, Kakinuma A, Ito H.
A newly established strain of spontaneously hypertensive rat with a defect of ascorbic acid biosynthesis.
Life Sci. 2001 Sep 7;69(16):1879-90.

Kawai K, Ito H, Kubota H, Takemori K, Makino S, Horio F.
Changes in catecholamine metabolism by ascorbic acid deficiency in spontaneously hypertensive rats unable to synthesize ascorbic acid.
Life Sci. 2003 Feb 28;72(15):1717-32.
Additional strain information SHR