Strain information
NBRP Rat No: 0732
Strain name
: SHRSP/2Kpo
Commmon Name: SHRSP A3-T-occ//Kpo
Rat Genome Database
Principal Investigator:
Yoshio Ohta Nara Hospital Kinki University Faculty of Medicine Otoda-cho, Ikoma-shi, 630-0293 Nara Japan
Tel: 074-377-0880 Fax:
Email: ohta@nara.med.kindai.ac.jp
Preservation Status:
Embryo
Sperm
Living Animals
Coat Color
アルビノ
Inbred Generations
F175
Usage Restrictions
The RECIPIENT must specify that SHRSP/2Kpo strain was bred and maintained at Kinki University Faculty of Medicine.
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
Okamoto et al. found some rats that have cerebrovascular lesion in SHR rats (espesially in line A). This strain was established in 1974 and named as "stroke-prone SHR (SHRSP) rat".
Strain characteristics
Life expectancy of this strain is a half of WKY rat (male: average 212 days, female: average 340 days). This strain shows similar symptoms to human stroke. The incidence of hypertensive cerebrovascular lesion is over 90% and this lesion tend to occur in the back of the head.
Breeding Conditions
Sib mating after cehcking phenotypes.
Genotyping
References
1. Establishment of the stroke-prone spontaneously hypertensive rat (SHR).
Okamoto K, Yamori Y, Nagaoka A.
Circ Res 1974, 34,35 (supppl): 143-153.
2. Developing an animal model for hypertension and utilizing in research.
Okamoto K.
Byotai-seiri 1982; 1: 459-472. (Japanese)
Additional strain information