Strain information
 NBRP Rat No: 0733  Strain name: MSHRSP/Kpo  Commmon Name: M-SHRSP A3-T-B/Kpo Rat Genome Database
Principal Investigator:  Yoshio Ohta  Nara Hospital Kinki University Faculty of Medicine       Otoda-cho, Ikoma-shi,    630-0293 Nara     Japan
Tel: 074-377-0880    Fax:  Email: ohta@nara.med.kindai.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  アルビノ
Inbred Generations  F183
Usage Restrictions  The RECIPIENT must specify that MSHRSP/Kpo strain was bred and maintained at Kinki University Faculty of Medicine.
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin Okamot et al. found that a few rats developed higher blood pressure (over 230 mmHg) at 10 weeks old. They selected SHRP rats that show severe hypertension from young age and M-SHRSP (malignant or precocious SHRSP) rat was established in 1985.
Strain characteristics Life expectancy of this strain is a half of SHRPS rat (male: average 90 days, female: average 120 days). This strain develop stroke symptoms earlier than SHRPS rat and the incidence of hypertensive cerebrovascular lesion is over 95%. Small or petechial hemorrhage is frequently observed in the base of the brain.
Breeding Conditions Sib mating after cehcking phenotypes.
Genotyping
References 1. Development of various types of hypertensive rats by crossbreeding of severe hypertensive with normotensive rats.
Okamoto, K, Yamamoto, K, Morita, N, Ohta Y.
In Hypertensive Mechanisms edited by Rasher W, Clough D, Ganten D. Sruttgart Schattauer, 1982, pp 143-146.
2. Establishment of characteristics of rat with precocious and severe hypertension (M-SHRSP).
Kozo Okamoto, Kazuo Yamamoto, Nobuko Morita and Yoshio Ohta.
Acta Med Kinki Univ Vol.10, No. 1, 73-95, 1985.
3. Establishment and Use of the M Strain of Stroke-Prone Spontaneously Hypertensive Rat.
Kozo Okamoto, Kazuo Yamamoto, Nobuko Morita, Yoshio Ohta. Taka-aki Chikugo, Tomoaki-Higashizawa and Tsuneyuki Suzuki.
Journal of Hypertension 1986, 4(supple 3): S21-S24.
Additional strain information