Strain information
 NBRP Rat No:   Strain name: ExHC/Seac  Commmon Name: Exogenously hypercholesterolemic rat
Principal Investigator:  Hidefumi Yukimasa  Takeda Chemical Industries, Ltd.       2-17-85, jusohonmati, yodogawa-ku    532-8686 Osaka     Japan
Tel: 06-6300-6868    Fax: 06-6300-6207 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/EXHC_Sea/441a%20(Large).jpg ../images/Photos/EXHC_Sea/441z%20(Large).jpg
Coat Color  albino (c)
Inbred Generations  
Usage Restrictions  "USER" shall not utilize "THE RESOUCE (ExHC/Seac)" for research aimed at discovering or validating drug candidates.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin Isolated from Sprague-Dawley (SD/Jcl) rats by Imai and Matsumura by selection for high serum cholesterol under high cholesterol diet for 7 days (app. 250 mg/dl, normal 100 mg/dl) in 1973. Kyushu University > Seac Yoshitomi, LTD. 1993
Strain characteristics Develop hypercholesterolemia for exogenous cholesterol. Hyperresponsivity to dietary cholesterol (Imaizumi et al. 1992).
Breeding Conditions When high cholesterol diet is not given to the ExHC/Seac rats, breeding performance is similar to that of SD strain. Significant QTLs for serum total cholesterol levels were revealed on chromosomes 5 and 14. A suggestive QTL for the trait was also detected on chromosome 3.
References Tanaka Y, Nagao K, Nakagiri H, Nagaso T, Iwasa Y, Mori H, Asahina M, Imaizumi K, Sato M.
Unavailability of liver triacylglycerol increases serum cholesterol concentration induced by dietary cholesterol in exogenously hypercholesterolemic (ExHC) rats.
Lipids Health Dis. 13:19, 2014.

Asahina M, Sato M, Imaizumi K.
Genetic analysis of diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats.
J Lipid Res. 46(10):2289-2294, 2005.

Imai Y, Matsumura H.
Genetic studies on induced and spontaneous hypercholesterolemia in rats.
Atherosclerosis. 1973 Jul-Aug;18(1):59-64.
Additional strain information ExHC