NBRP Rat No:
Commmon Name: Exogenously hypercholesterolemic rat
Hidefumi Yukimasa Takeda Chemical Industries, Ltd. 2-17-85, jusohonmati, yodogawa-ku 532-8686 Osaka Japan
Tel: 06-6300-6868 Fax: 06-6300-6207
"USER" shall not utilize "THE RESOUCE (ExHC/Seac)" for research aimed at discovering or validating drug candidates.
Research Area Others
Isolated from Sprague-Dawley (SD/Jcl) rats by Imai and Matsumura by selection for high serum cholesterol under high cholesterol diet for 7 days (app. 250 mg/dl, normal 100 mg/dl) in 1973. Kyushu University > Seac Yoshitomi, LTD. 1993
Develop hypercholesterolemia for exogenous cholesterol. Hyperresponsivity to dietary cholesterol (Imaizumi et al. 1992).
When high cholesterol diet is not given to the ExHC/Seac rats, breeding performance is similar to that of SD strain. Significant QTLs for serum total cholesterol levels were revealed on chromosomes 5 and 14. A suggestive QTL for the trait was also detected on chromosome 3.
Tanaka Y, Nagao K, Nakagiri H, Nagaso T, Iwasa Y, Mori H, Asahina M, Imaizumi K, Sato M.
Unavailability of liver triacylglycerol increases serum cholesterol concentration induced by dietary cholesterol in exogenously hypercholesterolemic (ExHC) rats.
Lipids Health Dis. 13:19, 2014.
Asahina M, Sato M, Imaizumi K.
Genetic analysis of diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats.
J Lipid Res. 46(10):2289-2294, 2005.
Imai Y, Matsumura H.
Genetic studies on induced and spontaneous hypercholesterolemia in rats.
Atherosclerosis. 1973 Jul-Aug;18(1):59-64.
Additional strain information