Strain information
NBRP Rat No: 0754
Strain name
: LEA.F344-
(D20Rat47-D20Mgh4)
/Tj
Commmon Name:
Rat Genome Database
Principal Investigator:
Keisuke Izumi Tokushima University 3-18-15 Kuramoto-cho, 770-8503 Tokushima-shi JAPAN
Tel: 088-633-7066 Fax: 088-633-7067
Email: izumi-k@tokushima-u.ac.jp
Preservation Status:
Embryo
Sperm
Living Animals
Coat Color
agouti
Inbred Generations
15
Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Origin
Long-Evans Agouti (LEA), type 2 diabetes model, dies from lymphocytic insulitis induced by radiation (4 Gy). This LEA.F344-(D20Rat47-D20Mgh4) strain is a congenic strain made by introducing a segment of chromosome 20 (D20Rat47-D20Mgh4) from F344 strain into LEA strain.
Strain characteristics
This rat strain develops type 2 diabetes. However, lymphocytic insulitis is not induced by X-ray radiation.
Breeding Conditions
Mating between male and female rat
Genotyping
PCR analysis by using microsatellite markers（D20Rat47, D20WOX3, D20Mgh4).
References
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Additional strain information