Strain information  NBRP Rat No: 0751  Strain name: SD-Tg(CAG-HRAS*G12V)246Htsu  Commmon Name: Hras246 Rat Genome Database Principal Investigator:  Hiroyuki Tsuda   Nagoya City University Graduate School of Medical Sciences       1 Kawasumi, Mizuho-cho Mizuho-ku, Nagoya    467-8601 Aichi     Japan Tel: 052-853-8992    Fax: 052-853-8996 Email: htsuda@med.nagoya-cu.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  白 Inbred Generations   Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain prior written consent concerning usage from the DEPOSITOR. In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected HRAS: v-Ha-ras Harvey rat sarcoma viral oncogene homolog [ Homo sapiens ] Origin The transgene consisting of CAG promoter/loxP/neomycin resistant gene casette/ lox/ Ha-ras*G12V（HrasV12）was injected into embryos of SD rat (Jcl:SD). this strain was generated at CLEA Japan,Inc. Strain characteristics Gene ezpression is controlled by Cre/LoxP system. Human activated HrasV12 expression is induced under CAG promoter and Cre recombinase. Breeding Conditions Genotyping References Ueda S, Fukamachi K, Matsuoka Y, Takasuka N, Takeshita F, Naito A, Iigo M, Alexander DB, Moore MA, Saito I, Ochiya T, Tsuda H. Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas. Carcinogenesis. 2006 Dec;27(12):2497-510. Additional strain information