Strain information
NBRP Rat No: 0753
Strain name
: F344-
Zeb2
em1Kyo
Commmon Name:
Rat Genome Database
Principal Investigator:
Takashi Kuramoto Graduate School of Medicine, Kyoto University Yoshidakonoe-cho, Sakyo-ku 606-8501 Kyoto Japan
Tel: 075-753-4494 Fax: 075-753-4409
Email: kuramot@anim.med.kyoto-u.ac.jp
Preservation Status:
Embryo
Sperm
Living Animals
Coat Color
albino
Inbred Generations
Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Category Other
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio Hypertension
Cancer
Metabolism
Otorhinology
Immunology
Infectious
Osteosis
Internal Organ
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Research Area Others
Control Strain
Marker Strain
Gene Affected
Zeb2: zinc finger E-box binding homeobox 2
Origin
Zinc-finger nucleases (ZFNs) method taregting exon 5 of Zeb2 gene (AGCCAAAGCTTGCCTCCA and GACTACTGACTCAAG) was used; This strain has a 5-bp deletion (cagag) and a 2-bp insertion (tc) in exon7 of Zeb2 gene, resulting in a deletion of Glutamine(Q)541. background strain: F344/Stm
Strain characteristics
No abnormalities in gross appearance and behavior. Good breeding performance
Breeding Conditions
sib mating between homozygous rats. Good breeding performance.
Genotyping
Zeb2_Small-F: CTCAGCCAGAAGAACAAGGG Zeb2_Small-R: CACAGGTAGCGTTCATGCTG Annealing temparature: 60℃
References
Additional strain information