NBRP Rat No: 0783
Commmon Name: Nrf2Δ7
Rat Genome Database
Masayuki Yamamoto Tohoku University 2-1, Seiryo-machi, Aoba-ku, Sendai 980-8575 Miyagi Japan
Tel: 022-717-8085 Fax: 022-717-8090
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The recipient must obey regulations stipulated in the liscence agreement of Sigma-Aldrich Co. LLC.
In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested: Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B 1 Toxicity. Taguchi K et al. Toxicol Sci (2016) 152 (1): 40-52.
A cooperative research is required for 2 years after depositing (DEPOSITOR should be included as co-authors).
In case of patent application based on research using this resource, a discussion with DEPOSITOR is needed.
Research Area Others
Nfe2l2：nuclear factor, erythroid 2-like 2
Zinc-finger nucleases (ZFNs) method taregting exon 5 of Nrf2 (ACCACTGTCCCCAGCCCAgaggccACACTGACAGAGATGGAC) was used; This strain has a 7-bp deletion in Nrf2 gene. Background strain: F344/Stm
Expression level of target gene of Nrf2 was decrerased by a deletion of Nrf2 transcription factor.
mating between heterozygous male and heterozygous female
Sequencing Nrf2 Small F TGAAAATGGGAGTTATCGGG Nrf2 Small R TGTGTTCAAGGTGGGATTTG
Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M.
Generation of A New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity.
Toxicol Sci. 2016 Jul;152(1):40-52.
Additional strain information