Origin
Tremor Rat which was found in a colony of outbred Wistar/Kyo in 1980 was separated to Tanabe Seiyaku Co., Ltd. in 1982.
This strain is a substrain of TRM/Kyo and does not show tremor behavior.
Strain characteristics
vacuole formation. Segregating inbred strain. No tremor behavior.
Breeding Conditions
Homozygous infertility. Maintained in heterozygous condition.
References
Yamada J, Serikawa T, Ishiko J, Inui T, Takada H, Kawai Y and Okaniwa A.
Rats with congenital tremor and curled whiskers and hair.
Jikken Dobutsu, 34: 183-188, 1985.
Serikawa T, Ohno Y, Sasa M, Yamada J and Takaori S.
A new model of petit mal epilepsy: spontaneous spike and wave discharges in tremor rats.
Lab Anim, 21: 68-71, 1987.
Kitada K, Akimitsu T, Shigematsu Y, Kondo A, Maihara T, Yokoi N, Kuramoto T, Sasa M and Serikawa T.
Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system.
J Neurochem, 74: 2512-2519, 2000.
Ohno Y, Shimizu S, Tatara A, Imaoku T, Ishii T, Sasa M, Serikawa T, Kuramoto T.
Hcn1 is a tremorgenic genetic component in a rat model of essential tremor.
PLoS One. 2015 May 13;10(5):e0123529.