NBRP Rat No: 0802
Commmon Name: LEH-
Rat Genome Database
Takashi Agui Graduate School of Veterinary Medicine Nishi 9 Kita 18 jou Kita-ku, Sapporo 060-0818 Hokkaido Japan
Tel: 011-706-5106 Fax: 011-706-5106
Users should be required an approval form from dipositor for 5 years after deposition.
Research Area Others
endothelin receptor type B: Ednrb
This strain derived from AR (aganglionosis) rat found by Dr. Ikadai in 1973. AR-derived Ednrb-sl was introduced into Long-Evans（NBRP-Rat # 0557 LE.AR-EdnrbSl/Okkm) by Dr. Ozaki and this rat was provided to Dr. Agui at Hokkaido University, and inbred line was established by sib mating.
Homozygous rats show auditory disorder (congenital deafness) and die of megacolon. This strain can survive longer than AGH rat and shows milder phenotype. Heterozygous (sl/+) rats don't show any phenotypes.
maintained in heterozygous condition
Forward Primer: CCTCCTGGACTAGAGGTTCC, Reverse Primer: ACGACTTAGAAAGCTACACT Product size wild-type：511 bp, mutant：210 bp
Dang et al. Genetic background strongly modifies the severity of symptoms of Hirschsprung disease, but not hearing loss in rats carrying Ednrb(sl) mutations. PLoS ONE (2011) vol. 6 (9) pp. e24086
Dang et al. Lymphopenia in Ednrb-deficient rat was strongly modified by genetic background. Biomed Res (2012) vol. 33 (4) pp. 249-53
Additional strain information