Strain information
 NBRP Rat No: 0807  Strain name: TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)/Nyo  Commmon Name: TM.KDP-Chr9,12,18 triple congenic Rat Genome Database
Principal Investigator:  Norihide Yokoi  Kobe University Graduate School of Medicine       Kobe BT Center, 1-5-6, Minatojima Minami-cho, Chuo-ku, Kobe    650-0047 Hyogo     Japan
Tel: 078-304-6046    Fax: 078-304-6057 Email:
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  fawn hooded (a,B,C,h,P,r)
Inbred Generations  N5F13(2015.3.8)
Usage Restrictions  Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Genetically Modified (GM)  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Cblb: Casitas B-lineage lymphoma b
Origin The Cblb mutaion, one of the causative gene in type 1 diabetes of KDP/Tky and KDP alleles in other modifier genes were transferred onto the genetic background of TM:Kyo strain.
Strain characteristics Cblb homozygous rats show mild to severe insulitis. The incidence of Type 1 diabetes is 20 to 50% (The onset of Type 1 diabetes is later and the incidence is lower than those of KDP rat strain.
Breeding Conditions Maintained as segregating inbred strain (Cblb mutaion: heterozygous). Homozygous Cblb rats are infertile in both sexes.
Genotyping PCR-RFLP analysis. primes Cblb-F:5'-TGCCCCTTCTGTCGCTGTGA-3', Cblb-R:5'-CCTCGGTTTTGAATCAACAG-3', TaqI digestion.
References Yokoi N, Komeda K, Wang HY, Yano H, Kitada K, Saitoh Y, Seino Y, Yasuda K, Serikawa T, Seino S.
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus.
Nat Genet. 31(4):391-4, 2002

Yokoi N, Namae M, Fuse M, Wang HY, Hirata T, Seino S, Komeda K.
Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain.
Exp Anim. 52(4):295-301, 2003

Yokoi N, Hayashi C, Fujiwara Y, Wang HY, Seino S.
Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat.
Diabetes. 56(2):506-512, 2007

Yokoi N, Hidaka S, Tanabe S, Ohya M, Ishima M, Takagi Y, Masui N, Seino S.
Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats.
Genes Immun. 13(2):139-145, 2012
Additional strain information