Strain information  NBRP Rat No: 0817  Strain name: CV/Iet  Commmon Name: Curly Vibrissae, CV Rat Genome Database Principal Investigator:  Akira Sato  The Institute of Environmental Toxicology           303-0043      Japan Tel: 0297-27-4537    Fax: 0297-27-4519 Email: a.satoh@iet.or.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  アルビノ Inbred Generations  F11 Usage Restrictions  1. Recipient agrees to cite the following paper in all written publications as related to the Material. Fujii S, Aoyama H, Takahashi KL, Kaneda M, Teramoto S. Curly vibrissae, a new mutation in the Wistar-derived rat. Congenit Anom (Kyoto). 43:65-71, 2003 2. The recipient of BIOLOGICAL RESOUCE shall obtain a prior written consent on use of it from the DEPOSITOR. 3. Depositors should be included as authors of the first research paper in which any attempts are made to identify the responsible mutation for cv/cv phonotypes. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin The Laboratory of Reproductive Toxicology at the Institute of Environmental Toxicology has been maintaining a Wistarderived PD strain of rats. In 1986, 1 female and 2 males exhibiting very short and sparse vibrissae were found in a litter of 7 parented by a pd/pd female and phenotypically normal pd/+ male. In 2008, a male Wistar rat and F56 female were corssed, and obtained heterozygous rats were sib-mated. After that, sib mating between homozygous rats was started. Strain characteristics Genetic analyses reveal that the mutant characteristics are inherited as autosomal recessive traits and the cv gene located on 10 Mb area（D8Got1-D8Got13) near Chr 8 centromere. This mutant rat is abnormally curled appearance of the vibrissae. The cv/cv homozygous rats have a small number of short and/or curly vibrissae around the nose. The vibrissae on the cheek andlor above the eyes are also short and curled; however, no vibrissa appears on the lower mandible. Although hair growth seems to be retarded, the outer hairs showed nearly normal length by 10 weeks of age. The outer hairs of matured cv/cv rats appear silky and translucent. The adult mutant rats often exhibit loss of hair on the head and/or back. Lactating females usually lose their abdominal hair. There is no histopathological change in the skin. Breeding Conditions Sib mating (crossing between homozygous rats) Genotyping References Fujii S, Aoyama H, Takahashi KL, Kaneda M, Teramoto S. Curly vibrissae, a new mutation in the Wistar-derived rat. Congenit Anom (Kyoto). 43:65-71, 2003. Additional strain information