Strain information
 NBRP Rat No: 0818  Strain name: PL/Iet  Commmon Name: Polydactyly Lethal, PL Rat Genome Database
Principal Investigator:  Akira Sato  The Institute of Environmental Toxicology           303-0043      Japan
Tel: 0297-27-4537    Fax: 0297-27-4519 Email: a.satoh@iet.or.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  アルビノ
Inbred Generations  不明
Usage Restrictions  Recipient agrees to cite the following paper in all written publications as related to the Material.

Aoyama H, Fujii S, Shirasu Y.
Polydactyly lethal: a new mutant spontaneously occurring in the FPL strain of rats.
J Hered. 82(5):397-401, 1991.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin A new mutant gene that causes preaxial polydactyly in the hindlimbs was found in the Jcl:Wistar -derived strain of rats with fused pulmonary lobes (FRL) at the Laboratory of Reproductive Toxicology at the Institute of Environmental Toxicology . Genetic analysis has revealed that the new mutation is not closely linked with the fpl gene. This strain was established by sib mating (over 20 generations).
Strain characteristics Genetic analysis has revealed that the new mutation is inherited as an autosomal recessive trait and is not closely linked with the fpl gene. The causative gene is not identified. Homozygous mutants have preaxial polydactyly in the hindlimbs and die within the first 2 days after birth. In some cases, phalangeal duplication or bifurcation in digit I with thickening of metacarpal I was also found in the forelimbs, although extra forelimb digits were not detected externally. The pl/pl newborns showed hunchback-like abnormal posture externally and had several associated vertebral abnormalities in varying degrees.
Breeding Conditions sib mating (heterozygous x heterozygous). Genotype is determined by test crossing because the causative gene of this strain has not yet been identified.
Genotyping Not established (The causative gene is not identified.)
References Aoyama H, Fujii S, Teramoto S, Shirasu Y.
Polydactyly lethal: a new mutant spontaneously occurring in the FPL strain of rats.
J Hered. 82(5):397-401, 1991.
Additional strain information