NBRP Rat No: 0821
Commmon Name: Hcn1 KO (Line84) , F344-
Rat Genome Database
Takashi Kuramoto Graduate School of Medicine, Kyoto University Yoshidakonoe-cho, Sakyo-ku 606-8501 Kyoto Japan
Tel: 075-753-4494 Fax: 075-753-4409
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Research Area Others
hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1)
TALEN (Left:ttcagＡＡＴＧＡＴＴＣＡＴＧＧＧ, Right:ＡＣＧＣＡＣＴＣＴＴＣＡＡＡＧＣＴＡ）targeting the exon4 of hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo.
A 7-bp deletion in the exon4 of Hcn1 gene: as a result of frameshift mutation, stop codon is produced. Decreased expression levels of Hcn1 gene and HCN1 protein.
maintained by crossing between homozygous and homozygous, or homozygous and heterozygous rats
rHcn1-e4-KO-F：ttccaaccatttgcctacaa rHcn1-e4-KO-R：gccataaccaatgcacagc PRODUCT SIZE：wild 239, KO 232
Additional strain information