Strain information
 NBRP Rat No: 0749  Strain name: F344-Phf24em2Kyo  Commmon Name: Phf24-null rat, F344-KIAA1045em2Kyo, KIAA1045-KO, Δ392 Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email: serikawa@anim.med.kyoto-u.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  アルビノ
Inbred Generations  F3 (2014年4月）
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected RGD1559864 (similar to mKIAA1045 protein) Rattus norvegicus
Origin In 2013, F344/Stm female rat deleted 392b (Δ392) of KIAA1045 (Phf24) was generated by Platinum TALEN methods.
Strain characteristics Although spontaneous GTCS is not observed, seizure susceptibility is increased and kindling induced by PTZ is promoted. In addition, locomotor activity is increased, disturbed behavior and spacial memory are decreased, and emotional behavior is increased due to unpleasant stimulation.
Breeding Conditions Sib mating (Δ392 homozygous mutant F344/Stm rats).
Genotyping Small F: 5’-CCCTGTGTAGGGTGCTGAACA-3’ / Small R: 5’-CGCTTCCTTCTCGTGTA-3’ (Product size: Δ392, None; Control F344, 385 bp) Large F: 5’-TGTGCACATGCATCTCTCTG-3’ / Large R: 5’-CCTTCCCCACGACTAATCCAA-3’ (Product size: Δ392, 602 bp; Control F344, 994 bp)
References Serikawa T, Kunisawa N, Shimizu S, Kato M, Alves Iha H, Kinboshi M, Nishikawa H, Shirakawa Y, Voigt B, Nakanishi S, Kuramoto T, Kaneko T, Yamamoto T, Mashimo T, Sasa M, Ohno Y.
Increased seizure sensitivity, emotional defects and cognitive impairment in PHD finger protein 24 (Phf24)-null rats.
Behav Brain Res. 2019 Sep 2;369:111922. doi: 10.1016/j.bbr.2019.111922. Epub 2019 Apr 27.
Additional strain information