Strain information  NBRP Rat No: 0929  Strain name: F344.LEA-Ugl/Okt  Commmon Name: Rat Genome Database Principal Investigator:  Tadashi Okamura  National Center for Global Health and Medicine       1-21-1 Toyama, Shinjyuku-ku, Tokyo    162-8655      Japan Tel: 03-3202-7181    Fax: 03-3202-7364 Email: yshimizu@ri.ncgm.go.jp (清水有紀子先生） Preservation Status:   Embryo        Sperm       Living Animals Coat Color  白色 Inbred Generations  N7 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The recipient is requested to cite the literature designated by the DEPOSITOR. Y. Shimizu, R. Yanobu-Takanashi, K. Nakano, K. Hamase, T. Shimizu & T. Okamura, A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats, Mamm.Genome 30 (2019) 23-33. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Ctns Origin A congenic strain in which the ugl locus of LEA/Tohm rats was introduced into F344/NSlc rats. Strain characteristics This strain is homozygous for the ugl locus, which contains a 13 bp deletion in the Ctns gene. Cystinosis model rat. Breeding Conditions Natural mating. Maintain by sib-mating. Genotyping References A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats. Shimizu Y, Yanobu-Takanashi R, Nakano K, Hamase K, Shimizu T, Okamura T. Mamm Genome. 2019 Feb;30(1-2):23-33. Additional strain information