Strain information
 NBRP Rat No: 0930  Strain name: F344.LEA-Idao/Okt  Commmon Name: Rat Genome Database
Principal Investigator:  Tadashi Okamura  National Center for Global Health and Medicine       1-21-1 Toyama, Shinjyuku-ku, Tokyo    162-8655      Japan
Tel: 03-3202-7181    Fax: 03-3202-7364 Email: yshimizu@ri.ncgm.go.jp (清水有紀子先生）
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  白色
Inbred Generations  N7
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The recipient is requested to cite the literature designated by the DEPOSITOR.
Y. Shimizu, C. Ishii, R. Yanobu-Takanashi, K. Nakano, A. Imaike, M. Mita, K. Hamase & T. Okamura, d-Amino acid oxidase deficiency is caused by a large deletion in the Dao gene in LEA rats, Biochim.Biophys.Acta Proteins Proteom 1868 (2020) 140463.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Dao
Origin A congenic strain in which the Idao locus of LEA/Tohm rats was introduced into F344/NSlc rats.
Strain characteristics This strain is homozygous for the Idao locus, which contains a 54.1 kb deletion in the Dao gene.
Breeding Conditions Natural mating. Maintain by brother-sister mating.
Genotyping
References d-Amino acid oxidase deficiency is caused by a large deletion in the Dao gene in LEA rats.
Shimizu Y, Ishii C, Yanobu-Takanashi R, Nakano K, Imaike A, Mita M, Hamase K, Okamura T.
Biochim Biophys Acta Proteins Proteom. 2020 Sep;1868(9):140463.
Additional strain information