Strain information
 NBRP Rat No: 0967  Strain name: SHRSP.SHR-(D1Got82-D1Rat97)/Izm  Commmon Name: Pr1.102, SPrch1.102 Rat Genome Database
Principal Investigator:  Toru Nabika, Hiroki Ohara  Shimane University, School of Medicine        89-1 Enya-cho,     693-8501 Izumo-City, Shimane-Prefecture     Japan
Tel: 0853-20-2407    Fax: 0853-20-2135 Email: oharah@med.shimane-u.ac.jp　（大原先生）　
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  白
Inbred Generations  
Usage Restrictions  Recipients are requested to obtain a written approval of the depositor.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin A subcongenic strain generated by backcrossing SHRSP.SHR-(D1Mgh5-D1Got87)/Izm (NBRP Rat No.0709) to SHRSP/Izm. A segment of the QTL region of chromosome 1 involved in salt-induced stroke (Niiya et al. Sci Rep. 2018; 8; 9403) has been exchanged.
Strain characteristics More resistant than SHRSP/Izm in stroke susceptibility testing under 1% saline loading conditions. Blood pressure (by tail-cuff method) at 12 weeks is comparable to SHRSP/Izm.
Breeding Conditions Maintained by homozygous sibling mating. Reproductive performance is good.
Genotyping Determined by PCR. Primers are as follows. D1Got82 (F: CCAAAAGTATGAGGCACGATA, R: ATTGTGCCATGGAGGCTCTCTG), D1Rat97 (F: AGGGGATTAGAAGCCTCTGC, R: TTCTCCCCTTTTTTCAGTCCCT)
References Wang M, Ohara H, Egawa M, Fukunaga S, Matsuo H, Ge ZR, Nabika T.
A 3-Mbp fragment on rat chromosome 1 affects susceptibility both to stroke and kidney injury under salt loading in the stroke-prone spontaneously hypertensive rat: a genetic approach using multiple congenic strains.
Exp Anim. 2022 Mar 29. doi: 10.1538/expanim.21-0189.
Additional strain information