Strain information  NBRP Rat No: 0950  Strain name: DA-Lystbg/Slc  Commmon Name: DA/Slc-bg/bg, beige rat Rat Genome Database Principal Investigator:  Representative Director  Japan SLC, Inc       3371-8, Kotoh-cho, Hamamatsu    431-1103 Shizuoka     Japan Tel: 053-486-3178    Fax: 053-486-3156 Email: slc01@jslc.co.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  Beige Inbred Generations   Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Lysosomal trafficking regulator(Lyst)遺伝子変異 Origin Lyst gene mutation was identified in 1985 in DA rats maintained at Hamamatsu University School of Medicine since 1980. In 2000, it was provided to Japan SLC, Inc. Strain characteristics Pale hair color, decreased NK cell activity, easy infection, spheroidal leukocytes with giant granules, and prolonged bleeding time. A model animal for Chediak-Higashi syndrome in humans. Breeding Conditions Maintained by sibling mating between bg/bg homozygous rats. Genotyping Genotyping is not performed because homozygous rats can breed with each other and can be determined by coat color. References Nishimura M., Inoue M., Nakano T., Nishikawa T., Miyamoto M., Kobayashi T., Kitamura Y.,　Beige Rat: A New Animal Model of Chediak-Higashi Syndrome. blood.V74.1.270-273(1989) Mori M., Nishikawa T., Higuchi K., Nishimura M., Deletion in the beige gene of the beige rat owing to recombination between LINE1s. Mamm Genome 10:692-695 (1999) Additional strain information