Strain information  NBRP Rat No: 1023  Strain name: W-Mkxem2Asah  Commmon Name: Rat Genome Database Principal Investigator:  Hiroshi Asahara  Tokyo Medical and Dental University       1-5-45, Yushima, Bunkyo-ku,Tokyo, Japan    113 - 8510 Tokyo     Japan Tel: 0358034614    Fax: 0358035810 Email: nakasyst@tmd.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  白 Inbred Generations  20回以上 Usage Restrictions  In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hidetsugu S. et al., Proc Nati Acard Scl U.S.A. (2016) 113, 7840-5 In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgement to the DEPOSITOR is requested. The reciipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Mkx Origin Deletion of 7 bases in the Mkx gene by CRISPR/Cas9. Genetic background is Slc:Wistar. Strain characteristics Tendon hypoplasia. Breeding Conditions Genotyping PCR and Sanger sequencing. References Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, Lotz MK, Okawa A, Asahara H. Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7840-5. Additional strain information