Strain information

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NBRP Rat No: 1023

Strain name: W-Mkx^em2Asah

Commmon Name:

Rat Genome Database

Principal Investigator:

Hiroshi AsaharaTokyo Medical and Dental University

Preservation Status:

Embryo Sperm Living Animals

Coat Color

白

Inbred Generations

20回以上

Usage Restrictions

In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Hidetsugu S. et al., Proc Nati Acard Scl U.S.A. (2016) 113, 7840-5
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgement to the DEPOSITOR is requested.
The reciipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Mkx

Origin

Deletion of 7 bases in the Mkx gene by CRISPR/Cas9. Genetic background is Slc:Wistar.

Strain characteristics

Tendon hypoplasia.

Breeding Conditions

Genotyping

PCR and Sanger sequencing.

References

Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, Lotz MK, Okawa A, Asahara H.
Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7840-5.

Additional strain information (Japanese only)