Strain information
 NBRP Rat No: 1029  Strain name: F344.W-np/Shi  Commmon Name: F344-np Rat Genome Database
Principal Investigator:  Masahiko Soga/ Toru Yanagimoto  Shionogi & Co., Ltd.       Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan    561-0825 Osaka     Japan
Tel: 07078126940    Fax: none Email: toru.yanagimoto@shionogi.co.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  
Inbred Generations  
Usage Restrictions  1) Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
2) The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
3) The BIOLOGICAL RESOURCE must not be provided to any third party without DEPOSITOR’s permission.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Not identified.
Origin In 1983, Wistar rats with pleural and ascites effusions and severe skin oedema were found at the Shionogi Pharmaceutical Co. The rats were named Nephrose Shionogi (NPS) because they showed nephrosis (F12). Breeding revealed that this phenotype was dominated by a autosomal recessive gene, np. NPS rats develop nephrosis at 4 weeks of age and die within 2 weeks. To prolong survival, NPS rats (np/+) were backcrossed with F344/Shi rats to generate the congenic strain (N12-13).
Strain characteristics This strain is a model animal for nephrotic syndrome with proteinuria, hypoproteinemia and hypercholesterolaemia. The phenotype is presumably governed by the autosomal recessive gene, np. Podocyte-specific morphological changes and decreased expression of slit diaphragm-associated proteins were observed, suggesting glomerular dysfunction.
Breeding Conditions
Genotyping As the gene has not been identified, the genotype is estimated by the progeny test. Homozygous rats show high levels of positive urinary protein from around 6 weeks of age. If such litters are observed, the parents are considered to be np/+ for both males and females. Heterozygous (np/+) rats are used for mating.
References 牧野進、山下浩文、野口順子、岸本嘉夫、林幸之、池内滋郎、吉崎敏夫、森浩志 遺伝性ネフローゼラットの発現とその特性 第31回日本実験動物学会（1984年）
岸本嘉夫、野口順子、山下浩文、牧野進、林幸之、森浩志 遺伝性ネフローゼラットの腎病変について 第32回日本実験動物学会（1985年）
Additional strain information