Strain information
 NBRP Rat No: 1012  Strain name: F344-ROSA26em20(Alb-cre)Larc  Commmon Name: F344-ROSA26-Alb-Cre　Line20 Rat Genome Database
Principal Investigator:  Masayuki Yamamoto  Tohoku University       2-1, Seiryo-machi, Aoba-ku, Sendai     980-8575 Miyagi     Japan
Tel: 022-717-8085    Fax: 022-717-8090 Email: masayuki.yamamoto.c7@tohoku.ac.jp
Preservation Status:   Embryo        Sperm       Living Animals
Coat Color  アルビノ
Inbred Generations  F1
Usage Restrictions  In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature Designated by the DEPOSITOR is requested.
Ishida S, Taguchi K, Iida R, Hattori K, Taketsuru H, Yoshimi K, Yamamoto M, Mashimo T.
Diverse Cre recombinase expression pattern in Albumin-Cre driver rats.
Exp Anim. 2025 Jul 11;74(3):328-334.

The following specific terms and conditions are requested by the DEPOSITOR. In this event, the recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
1.This collaboration using this resource needs co-authorship.
2.Further discussion is needed, when a patent is applied on researches using this resource.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected ROSA26
Origin This strain was created at the Institute of Medical Science, University of Tokyo using the CRISPR-Cas9 method. F344/Jcl rat fertilized eggs were microinjected and then transplanted into the oviducts of pseudopregnant females. From the resulting offspring, rats with the Alb promoter-Cre sequence inserted into the ROSA26 gene were selected and established. The Alb promoter-Cre sequence is inserted in an inverted position.
Strain characteristics Cre is expressed specifically in the liver.
Breeding Conditions Maintained by crossing heterozygous rats with wild type rats.
Genotyping The genotype is determined by PCR and electrophoresis.
References Ishida S, Taguchi K, Iida R, Hattori K, Taketsuru H, Yoshimi K, Yamamoto M, Mashimo T.
Diverse Cre recombinase expression pattern in Albumin-Cre driver rats.
Exp Anim. 2025 Jul 11;74(3):328-334.
Additional strain information