Strain information  NBRP Rat No: 1012  Strain name: F344-ROSA26em20(Alb-cre)Larc  Commmon Name: F344-ROSA26-Alb-Cre　Line20 Rat Genome Database Principal Investigator:  Masayuki Yamamoto  Tohoku University       2-1, Seiryo-machi, Aoba-ku, Sendai     980-8575 Miyagi     Japan Tel: 022-717-8085    Fax: 022-717-8090 Email: masayuki.yamamoto.c7@tohoku.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  アルビノ Inbred Generations  F1 Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected ROSA26 Origin This strain was created at the Institute of Medical Science, University of Tokyo using the CRISPR-Cas9 method. F344/Jcl rat fertilized eggs were microinjected and then transplanted into the oviducts of pseudopregnant females. From the resulting offspring, rats with the Alb promoter-Cre sequence inserted into the ROSA26 gene were selected and established. The Alb promoter-Cre sequence is inserted in an inverted position. Strain characteristics Cre is expressed specifically in the liver. Breeding Conditions Maintained by crossing heterozygous rats with wild type rats. Genotyping The genotype is determined by PCR and electrophoresis. References Ishida S, Taguchi K, Iida R, Hattori K, Taketsuru H, Yoshimi K, Yamamoto M, Mashimo T. Diverse Cre recombinase expression pattern in Albumin-Cre driver rats. Exp Anim. 2025 Jan 22. Additional strain information