Usage Restrictions
In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested (*).
Origin
Founded from a breeding colony of Wistar by Ohno at Yagi Memorial Park in 1988. A congenic line BN-dop and an inbred line DOP-dop were established.
Strain characteristics
Normal behaviour until day 10, thereafter, excessive spinning around on smooth surfaces and tendency to be off balance. Slight convulsive limb movements. Can't regain upright posture. Limb convulsion associated with opisthotonus becomes tetanic. Hyperacuety. Dead after 3 weeks. Lighter coat color pigmentation. Controlled by an autosomal recessive gene (Dekker-Ohno et al. 1993).
Breeding Conditions
Maintained by crossing heterozygotes of the dop locus (segregating inbred strain).
References
* Dekker-Ohno K, Oda S, Yamamura H, Kondo K.
An ataxic mutant rat with dilute coat color.
Lab Anim Sci. 1993 Aug;43(4):370-2
* Futaki S, Takagishi Y, Hayashi Y, Ohmori S, Kanou Y, Inouye M, Oda S, Seo H, Iwaikawa Y, Murata Y.
Identification of a novel myosin-Va mutation in an ataxic mutant rat, dilute-opisthotonus.
Mamm Genome. 2000 Aug;11(8):649-55.
* Dekker-Ohno K, Hayasaka S, Takagishi Y, Oda S, Wakasugi N, Mikoshiba K, Inouye M, Yamamura H.
Endoplasmic reticulum is missing in dendritic spines of Purkinje cells of the ataxic mutant rat.
Brain Res. 1996 Apr 1;714(1-2):226-30
* Miyata M, Finch EA, Khiroug L, Hashimoto K, Hayasaka S, Oda SI, Inouye M, Takagishi Y, Augustine GJ, Kano M.
Local calcium release in dendritic spines required for long-term synaptic depression.
Neuron. 2000 Oct;28(1):233-44