Strain information
 NBRP Rat No: 0085  Strain name: HOB/Snk  Commmon Name: HOB, hobble rat Rat Genome Database
Principal Investigator:  Yosuke Ando  DAIICHI SANKYO Co., Ltd.       717, Horikoshi, Fukuroi-shi    437-0065 Shizuoka     JAPAN
Tel: 0538-42-4356    Fax: 0538-42-4350 Email: ando.yosuke.x8@daiichisankyo.co.jp
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/HOB%20(hob%20hob)/751a%20(Large).jpg ../images/Photos/HOB%20(hob%20hob)/751z%20(Large).jpg
Coat Color  a,B,C,h
Inbred Generations  
Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Unc5c: unc-5 homolog C (C. elegans)
Origin HOB rat was identified in the F344 congenic rats (N12F13) to which the coat color locus (C) of fatty rat has been transferred in Sankyo Co., Ltd. Introduced to Kyoto University in 1999 at F13.
Strain characteristics Abnormal behavior with a swaying gait due to hind-leg paralysis is observed at 2-3 weeks after birth. Reproductivity of affected (hob/hob) males is extremely low. Pathological examination on the cerebellum shows flat shape, vermis defect, partially invaginated molecular layer, and ectopic Purkinje cells. The hob is allelic to the cvd on the Unc5h3 locus. Please refer to NBRP No.0084.
Breeding Conditions Maintained in sib mating between hob/+ male and hob/hob female. Good breeding performance.
Genotyping PCR-RFLP（see Kuramoto et al. Mol. Brain Res. 122(2): 103-108, 2004) Genotyping protocol for Unc5c
References Kuwamura M, Ando Y, Takeda A, Kanehara T, Yamane J, Kotani T, Takeshita S, Kanbori M, Kitada, K, Serikawa, T.
Rat mutations cvd and hob with cerebellar malformations map to chromosome 2.
Exp. Anim. 53(1): 21-26, 2004.

Kuramoto T, Kuwamura M, Serikawa T.
Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3.
Brain Res Mol Brain Res. 122(2): 103-108, 2004.
Additional strain information HOB