| NBRP Rat No: 0096 |
Strain name: BUF.ACI-(D3Rat56-D3Rat83)/Ncc |
Commmon Name: BUF.ACI-Gcr2/Ncc, BUF.ACI-Gcr2 |
Rat Genome Database |
| Principal Investigator: |
Toshikazu Ushijima National Cancer center 5-1-1 Tsukiji, Chuo-ku 104-0045 Tokyo JAPAN |
| Tel: 03-3547-5240 Fax: 03-5565-1753 |
Email: tushijim@ncc.go.jp |
| Preservation Status: |
Embryo Sperm Living Animals |
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| Coat Color |
albino (c) |
| Inbred Generations |
N5F12 |
| Usage Restrictions |
In publishing, an acknowledgment to the DEPOSITOR is requested |
| Genetic Status |
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| Comercial Availability |
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| Research Category |
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| Gene Affected |
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| Origin |
This congenic strain is homozygous for the ACI/N Gcr2 allele (on chr.3) on the BUF/Nac background (Yamashita, 2005).
ACI/N rats are susceptible and BUF/Nac rats are resistant to MNNG-induced stomach carcinogenesis, and the presence of an autosomal gene with a dominant BUF allele has been suggested. By using ACI x (ACIxBUF) F1 backcross rats, one dominant susceptibility gene, Gcs1 (Gastric cancer susceptibility gene 1), and three dominant resistance genes, Gcr1 (Gastric cancer resistance gene 1), Gcr2 and Gcr3 have been mapped on chromosome 4, 3 and 16 respectively by QTL analysis for MNNG-induced stomach carcinogenicity (Ushijima, 2000). (Feb 4, 2008) |
| Strain characteristics |
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| Breeding Conditions |
Good breeding performance. |
| Genotyping |
D3Rat56, D3Rat83 |
| References |
Ushijima T, Yamamoto M, Suzui M, Kuramoto T, Yoshida Y, Nomoto T, Tatematsu M, Sugimura T, Nagao M.
Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas.
Cancer Res, 60:1092-1096, 2000
Yamashita S, Wakazono K, Nomoto T, Tsujino Y, Kuramoto T, Ushijima T.
Expression quantitative trait loci analysis of 13 genes in the rat prostate.
Genetics. 2005 171(3):1231-8. |
| Additional strain information |
BUF ACI |
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