Origin
WTC was established as a coisogenic strain (tm<+/+>) from TRM (F18) in 1988. A missense mutation (c. 1061 C>T, p. A354V) in the hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene (Ohno et al. 2015).
Strain characteristics
Control coisogenic strain of TRM rat (NBRP No.0015).
Breeding Conditions
Good breeding performance. Sib mating.
References
Hieu HT, Tanaka M, Kuwamura M, Mashimo T, Serikawa T, Kuramoto T.
The rat Downunder (Du) coat color mutation is associated with eye anomalies and embryonic lethality and maps to a 3.9-Mb region on chromosome 3.
Exp Anim. 2023 Feb 21;72(1):88-94.
Nagaki Y, Ito K, Kuwahara M.
WTC rat has unique characteristics such as resistant to streptozotocin.
Biochemistry and Biophysics Reports, Volume 8, December 2016, Pages 157–161
Y. Ohno, S. Shimizu, A. Tatara, T. Imaoku, T. Ishii, M. Sasa, T. Serikawa, T. Kuramoto.
Hcn1 is a tremorgenic genetic component in a rat model of essential tremor.
PLoS One. 2015 May 13;10(5):e0123529.
Yoshihara M, Saito D, Sato T, Ohara O, Kuramoto T, Suyama M.
Design and application of a target capture sequencing of exons and conserved non-coding sequences for the rat.
BMC Genomics. 2016 Aug 9;17:593.
Kuramoto T, Nakanishi S, Ochiai M, Nakagama H, Voigt B, Serikawa T.
Origins of Albino and Hooded Rats: Implications from Molecular Genetic Analysis across Modern Laboratory Rat Strains.
PLoS One. 2012;7(8):e43059.
Kuramoto T, Yokoe M, Hashimoto R, Hiai H, Serikawa T.
A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene.
BMC Genetics 12:91, 2011