Strain information  NBRP Rat No: 0103  Strain name: LEW/JmsNgs  Commmon Name: LEW/Jms, congenital hydrocephalus rat, 先天性水頭症ラット Rat Genome Database Principal Investigator:  Kazutaka Ohsawa  Center for Frontier Life Sciences, Nagasaki University       1-12-4, Sakamoto, Nagasaki    852-8523 Nagasaki     Japan Tel: 095-819-7132    Fax: 095-819-7148 Email: kohsawa@net.nagasaki-u.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  F71+9+25 (April 2012) Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin Lewis rats: Tokyo Medical Insitute -> Seiwa Institute of Experimental Animals, Hydrocephalus was found the rats at F27 in 1980 -> Dr. Yasutaka Noda at Center for Animal Experiments, Kurume University, The hydrocephalus rat strains have been maitained out by selective breeding. Strain characteristics Congenital hydrocephalus. Appearance of hydocephalus rats: about 33% in males, about 13 % in females. Breeding Conditions For an optimal breeding performance, 20% of the colony should develop hydrocephalus. Selection for higher disease occurrence reduces breeding efficiency due to infertle animals. Genotyping References ・小児の脳神経９（４）：257-264,1984　ラットにおける先天性水頭症の実験モデル ・脳神経３７（１１）：1053-1057,1985　先天性水頭症ラット（LEW/Jms）における脳組織障害について ・小児の脳神経１２（１）：1-9,1987　先天性水頭症ラット脳の病理学的観察 ・脳神経４２（６）：539-545,1990　先天性水頭症ラット脈絡叢における心房性ナトリウム利尿ペプチド受容体の変動 Additional strain information LEW