Strain information  NBRP Rat No: 0104  Strain name: WIC-Tgrdw/Kts  Commmon Name: WIC-rdw, rdw Rat Genome Database Principal Investigator:  Sen-ichi Furudate  School of Medicine, Kitasato University       1-15-1, Kitasato, Sagamihara    228-8555 Kanagawa     Japan Tel: 042-778-9319    Fax: 042-778-7555 Email: furudate@med.kitasato-u.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  F15+13 (08.5.30) Usage Restrictions  In publishing, an acknowledgment to the DEPOSITOR is requested Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Tg: thyroglobulin Origin The WIC-rdw rat, established from a closed colony of Wistar-Imamichi (WIC) rats as a spontaneous mutant exhibiting congenital dwarfism (rdw), is inherited as an autosomal recessive. Strain characteristics A convincing line of evidence is being developed that the congenital nongoitrous hypothyroidism and dwarfism observed in the WIC-rdw rat may indeed be caused by a primary defect in thyroid hormonogenesis. In support of this hypothesis, several recent reports have shown the presence of elevated molecular chaperone levels in the WIC-rdw thyrocytes, the endoplasmic reticulum of which was markedly dilated, suggesting a defect in intracellular protein transport. It was reported that A missense mutation, G2320R, in the Tg gene is responsible for the rdw mutation in the WIC-rdw rat. Breeding Conditions Homozygous rdw rats are infertile in both sexes. So, the mutant rats are maintained as a segregating inbred strain. Genotyping Genotyping protocol for Tg References Zhang X, Malik B, Young C, Zhang H, Larkin D, Liao XH, Refetoff S, Liu M, Arvan P. Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood. J Biol Chem. 2022 Jul;298(7):102066. Zhang X, Kellogg AP, Citterio CE, Zhang H, Larkin D, Morishita Y, Targovnik HM, Balbi VA, Arvan P. Thyroid hormone synthesis continues despite biallelic thyroglobulin mutation with cell death. JCI Insight. 2021 Jun 8;6(11):e148496. Shibayama K, Ohyama Y, Ono M, Furudate S Expression of mRNA coding for pituitary hormones and pituitary-specific transcription factor in the pituitary gland of the rdw rat with hereditary dwarfism. J Endocrinol. 138: 307-313, 1993. Ono M, Harigai T, Furudate S. Pituitary-specific transcription factor Pit-1 in rdw rat with GH- and PRL- deficient dwarfism. J. Endocrinol. 143, 479-487, 1994. Oh-Ishi M, Omori A, Kwon JY, Agui T, Maeda T, Furudate S. Detecion and identication of proteins related to the hereditary dwarfism of the rdw rat. Endocrinology 139(3): 1288-1299, 1998. Hishinuma A, Furudate S, Oh-ishi M, Nagakubo N, Namatame T, Ieiri T A novel missense mutation (G2320R) of the thyroglobulin gene causes hereditary hypothyroidism of the rdw rat. Endocrinology 141 (11): 4050-4055, 2000. Sakai Y, Yamashina S, Furudate S Missing Secretory Granules, dilated Endoplasmic reticulum, and nuclear dislocation in the thyroid gland of rdw rats with hereditary dwarfism. Anat Rec 259: 60-66, 2000. Kim PS, Ding M, Menon S, Jung C-G, Cheng J-M, Miyamoto T, Li B, Furudate S, Agui T A missence mutation G2320R in the thyroglobulin gene causes non-goitrous congenital primary hypothyroidism in the WIC-rdw rat. Mol Endocrinol 14 (12): 1944-1953, 2000. Additional strain information WIC