| NBRP Rat No: 0104 |
Strain name: WIC-Tgrdw/Kts |
Commmon Name: WIC-rdw, rdw |
Rat Genome Database |
| Principal Investigator: |
Sen-ichi Furudate School of Medicine, Kitasato University 1-15-1, Kitasato, Sagamihara 228-8555 Kanagawa Japan |
| Tel: 042-778-9319 Fax: 042-778-7555 |
Email: furudate@med.kitasato-u.ac.jp |
| Preservation Status: |
Embryo Sperm Living Animals |
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| Coat Color |
albino (c) |
| Inbred Generations |
F15+13 (08.5.30) |
| Usage Restrictions |
In publishing, an acknowledgment to the DEPOSITOR is requested |
| Genetic Status |
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| Comercial Availability |
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| Research Category |
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| Gene Affected |
Tg: thyroglobulin |
| Origin |
The WIC-rdw rat, established from a closed colony of Wistar-Imamichi (WIC) rats as a spontaneous mutant exhibiting congenital dwarfism (rdw), is inherited as an autosomal recessive. |
| Strain characteristics |
A convincing line of evidence is being developed that the congenital nongoitrous hypothyroidism and dwarfism observed in the WIC-rdw rat may indeed be caused by a primary defect in thyroid hormonogenesis. In support of this hypothesis, several recent reports have shown the presence of elevated molecular chaperone levels in the WIC-rdw thyrocytes, the endoplasmic reticulum of which was markedly dilated, suggesting a defect in intracellular protein transport. It was reported that A missense mutation, G2320R, in the Tg gene is responsible for the rdw mutation in the WIC-rdw rat. |
| Breeding Conditions |
Homozygous rdw rats are infertile in both sexes. So, the mutant rats are maintained as a segregating inbred strain. |
| Genotyping |
Genotyping protocol for Tg |
| References |
Shibayama K, Ohyama Y, Ono M, Furudate S
Expression of mRNA coding for pituitary hormones and pituitary-specific transcription factor in the pituitary gland of the rdw rat with hereditary dwarfism. J Endocrinol. 138: 307-313, 1993.
Ono M, Harigai T, Furudate S.
Pituitary-specific transcription factor Pit-1 in rdw rat with GH- and PRL- deficient dwarfism.
J. Endocrinol. 143, 479-487, 1994.
Oh-Ishi M, Omori A, Kwon JY, Agui T, Maeda T, Furudate S.
Detecion and identication of proteins related to the hereditary dwarfism of the rdw rat.
Endocrinology 139(3): 1288-1299, 1998.
Hishinuma A, Furudate S, Oh-ishi M, Nagakubo N, Namatame T, Ieiri T
A novel missense mutation (G2320R) of the thyroglobulin gene causes hereditary hypothyroidism of the rdw rat.
Endocrinology 141 (11): 4050-4055, 2000.
Sakai Y, Yamashina S, Furudate S
Missing Secretory Granules, dilated Endoplasmic reticulum, and nuclear dislocation in
the thyroid gland of rdw rats with hereditary dwarfism.
Anat Rec 259: 60-66, 2000.
Kim PS, Ding M, Menon S, Jung C-G, Cheng J-M, Miyamoto T, Li B, Furudate S, Agui T
A missence mutation G2320R in the thyroglobulin gene causes non-goitrous congenital primary hypothyroidism in the WIC-rdw rat.
Mol Endocrinol 14 (12): 1944-1953, 2000. |
| Additional strain information |
WIC |
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