Strain information  NBRP Rat No: 0028  Strain name: KZC/Tky  Commmon Name: KZC, Komeda Zucker Creeping rat Rat Genome Database Principal Investigator:  Eiichi Kawamoto  Tokyo Medical University       6-1-1 Shinjuku, Shinjuku-ku,    160-8402 Tokyo     JAPAN Tel: 03-3351-6141    Fax: 03-3350-8689 Email: kawamoto@tokyo-med.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  black hooded (a,B,C,h) Inbred Generations  F45 Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Reln: reelin Origin Komeda Zucker Creeping rat derived from a closed colony of the Zucker fatty rat by spontaniously mutation at Tokyo Medical College in 1983. Strain characteristics The animals exhibiting severe ataxia with staggering gait and tremor at about 14 days of age, and die around 4 weeks of age. The cerebellum of the mutants shows severe hypoplasia with the reduction of the molecular and granular layers and malposition of Purkinje cells in the white matter. The abnormal pathological changes are also detected in the cerebrum, including the absence of a well-defined outer molecular layer, no typical lamination, and irregular cell arrangement in the hippocampus. Breeding Conditions Homozygous Reln Genotyping One base insertion detected by PCR-direct sequencing. References Nakanishi S, Kuramoto T, Kashiwazaki N, Yokoi N. Genetic profiling of two phenotypically distinct outbred rats derived from a colony of the Zucker fatty rats maintained at the Tokyo Medical University. Exp Anim. 2016 Oct 31. [Epub ahead of print] Yokoi N, Namae M, Wang HY, Kojima K, Fuse M, Yasuda K, Serikawa T, Seino S, Komeda K. Rat neurological disease creeping is caused by a mutation in the reelin gene. Brain Res Mol Brain Res. 10;112(1-2):1-7, 2003. Yokoi N, Shimizu S, Ishibashi K, Kitada K, Iwama H, Namae M, Sugawara M, Serikawa T, Komeda K. Genetic mapping of the rat mutation creeping and evaluation of its positional candidate gene reelin. Mamm Genome. 11(2):111-4, 2000. Ishibashi K, Komeda K, Sekiguchi F, Kanazawa Y. Creeping: a new mutant rat with neurological disease. Lab Anim Sci. 39(2):132-6, 1989. Additional strain information KZC