Strain information  NBRP Rat No: 0023  Strain name: WTC.ZI-Atrnzi/Kyo  Commmon Name: WTC.ZI-Atrnzi, WTC.ZI-zi Rat Genome Database Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN Tel: 075-753-4360    Fax: 075-753-4409 Email: serikawa@anim.med.kyoto-u.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  N23F29 (March 2012) Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Atrn: attractin Origin Zitter rat was detected in a Sprague Dawley colony (SD) in Hannover in 1978 by Rehm. 1983 introduced to Kyoto University and established ZI/Kyo. A second zi allele carrying line with WTC backgrund was established at Kyoto University WTC.ZI-zi. Strain characteristics This strain exhibits vacuole formation of CNS and body tremor. The causative gene is Atrm (attractin). Breeding Conditions Heterozygous female and homozygous male are mated. Genotyping 8 bp deletion in intron 12 of Attractin gene Genotyping protocol for Atrn References Muto Y, Sato K. Pivotal role of attractin in cell survival under oxidative stress in the zitter rat brain with genetic spongiform encephalopathy. Brain Res Mol Brain Res. 2003 Mar 17;111(1-2):111-22. Kuramoto T, Kitada K, Inui T, Sasaki Y, Ito K, Hase T, Kawagachi S, Ogawa Y, Nakao K, Barsh GS, Nagao M, Ushijima T, Serikawa T. Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system. Proc Natl Acad Sci USA, 98 (2): 559-564, 2001 Kuramoto T, Yamasaki K, Kondo A, Nakajima K, Yamada M, Serikawa T. Production of WTC.ZI-zi rat congenic strain and its pathological and genetic analyses. Exp Anim, 47: 75-81, 1998 Additional strain information WTC ZI