Strain information
 NBRP Rat No: 0023  Strain name: WTC.ZI-Atrnzi/Kyo  Commmon Name: WTC.ZI-Atrnzi, WTC.ZI-zi Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/WTC.ZI-zi/621a%20(Large).jpg ../images/Photos/WTC.ZI-zi/621z%20(Large).jpg
Coat Color  albino (c)
Inbred Generations  N23F29 (March 2012)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Atrn: attractin
Origin Zitter rat was detected in a Sprague Dawley colony (SD) in Hannover in 1978 by Rehm. 1983 introduced to Kyoto University and established ZI/Kyo. A second zi allele carrying line with WTC backgrund was established at Kyoto University WTC.ZI-zi.
Strain characteristics This strain exhibits vacuole formation of CNS and body tremor. The causative gene is Atrm (attractin).
Breeding Conditions Heterozygous female and homozygous male are mated.
Genotyping 8 bp deletion in intron 12 of Attractin gene Genotyping protocol for Atrn
References Muto Y, Sato K.
Pivotal role of attractin in cell survival under oxidative stress in the zitter rat brain with genetic spongiform encephalopathy.
Brain Res Mol Brain Res. 2003 Mar 17;111(1-2):111-22.

Kuramoto T, Kitada K, Inui T, Sasaki Y, Ito K, Hase T, Kawagachi S, Ogawa Y, Nakao K, Barsh GS, Nagao M, Ushijima T, Serikawa T.
Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system.
Proc Natl Acad Sci USA, 98 (2): 559-564, 2001

Kuramoto T, Yamasaki K, Kondo A, Nakajima K, Yamada M, Serikawa T.
Production of WTC.ZI-zi rat congenic strain and its pathological and genetic analyses.
Exp Anim, 47: 75-81, 1998
Additional strain information WTC ZI